High concentration of branched‐chain amino acids promotes oxidative stress, inflammation and migration of human peripheral blood mononuclear cells via mTORC1 activation
Sign Up to like & getrecommendations! Published in 2017 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2017.01.009
Abstract: ABSTRACT Leucine, isoleucine and valine are essential aminoacids termed branched‐chain amino acids (BCAA) due to its aliphatic side‐chain. In several pathological and physiological conditions increased BCAA plasma concentrations have been described. Elevated BCAA levels predict… read more here.
Keywords: chain; migration; blood; bcaa ... See more keywords
OLIVe: A Genetically Encoded Fluorescent Biosensor for Quantitative Imaging of Branched-Chain Amino Acid Levels inside Single Living Cells.
Sign Up to like & getrecommendations! Published in 2019 at "ACS sensors"
DOI: 10.1021/acssensors.9b02067
Abstract: Branched-chain amino acids (BCAAs) are essential amino acids, controlling cellular metabolic processes as signaling molecules; therefore, utilization of intracellular BCAAs may be regulated by the availability of nutrients in the environment. However, spatial and temporal… read more here.
Keywords: amino; bcaa concentrations; biosensor; bcaa ... See more keywords
Acetylation promotes BCAT2 degradation to suppress BCAA catabolism and pancreatic cancer growth
Sign Up to like & getrecommendations! Published in 2020 at "Signal Transduction and Targeted Therapy"
DOI: 10.1038/s41392-020-0168-0
Abstract: Pancreatic ductal adenocarcinoma (PDAC) is well-known for inefficient early diagnosis, with most patients diagnosed at advanced stages. Increasing evidence indicates that elevated plasma levels of branched-chain amino acids (BCAAs) are associated with an increased risk… read more here.
Keywords: degradation; bcat2; pancreatic cancer; bcaa ... See more keywords
Newly characterized mitochondrial BCAA transporter
Sign Up to like & getrecommendations! Published in 2019 at "Nature Reviews Endocrinology"
DOI: 10.1038/s41574-019-0262-y
Abstract: Emerging evidence suggests that brown adipose tissue (BAT) has roles outside of thermogenesis, including acting as a metabolic sink for glucose and fatty acids. Now, Shingo Kajimura and colleagues report that the catabolism of branched-chain… read more here.
Keywords: bcaas; bat; mitochondrial bcaa; bcaa ... See more keywords
Omega-3 fatty acids enhance the beneficial effect of BCAA supplementation on muscle function following eccentric contractions
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the International Society of Sports Nutrition"
DOI: 10.1080/15502783.2022.2117994
Abstract: ABSTRACT Background This study investigated the combined effect of branched-chain amino acids (BCAA) and fish oil (FO) on muscle damage caused by eccentric contractions (ECCs) of the elbow flexors, with a special focus on muscular… read more here.
Keywords: bcaa; eccentric contractions; muscle; group ... See more keywords
Autophagy contributes to sulfonylurea herbicide tolerance via GCN2-independent regulation of amino acid homeostasis
Sign Up to like & getrecommendations! Published in 2018 at "Autophagy"
DOI: 10.1080/15548627.2017.1407888
Abstract: ABSTRACT Sulfonylurea (SU) herbicides inhibit branched-chain amino acid (BCAA) biosynthesis by targeting acetolactate synthase. Plants have evolved target-site resistance and metabolic tolerance to SU herbicides; the GCN2 (general control non-repressible 2) pathway is also involved… read more here.
Keywords: amino acid; tolerance; gcn2; autophagy ... See more keywords
Diabetes and branched‐chain amino acids: What is the link?
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Diabetes"
DOI: 10.1111/1753-0407.12645
Abstract: Branched-chain amino acids (BCAA) have increasingly been studied as playing a role in diabetes, with the PubMed search string "diabetes" AND "branched chain amino acids" showing particular growth in studies of the topic over the… read more here.
Keywords: chain; insulin; amino acids; branched chain ... See more keywords
Prospective study of dietary intake of branched-chain amino acids and the risk of primary open-angle glaucoma.
Sign Up to like & getrecommendations! Published in 2021 at "Acta ophthalmologica"
DOI: 10.1111/aos.14971
Abstract: PURPOSE Metabolomic and preclinical studies suggest that branched-chain amino acids (BCAA) may be inversely associated with neurodegenerative diseases including glaucoma. We therefore assessed the long-term association between dietary intake of BCAA and incident primary open-angle… read more here.
Keywords: poag; dietary intake; intake; study ... See more keywords
BrnQ-Type Branched-Chain Amino Acid Transporters Influence Bacillus anthracis Growth and Virulence
Sign Up to like & getrecommendations! Published in 2022 at "mBio"
DOI: 10.1128/mbio.03640-21
Abstract: Infection with B. anthracis can result in systemic disease with large numbers of the bacterium in multiple tissues. We found that branched-chain amino acid (BCAA) synthesis is insufficient for the robust growth of B. anthracis;… read more here.
Keywords: virulence; chain amino; amino acid; growth ... See more keywords
Abstract 4188: Preoperative supplementation of branched-chain amino acids suppresses Osteopontin expression in patients with hepatocellular carcinoma
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-4188
Abstract: Background: Recently, the new effect of branched-chain amino acid (BCAA) on Osteopontin (OPN), which correlates with cancer progression, has been reported. The aim of this study was that preoperative administration of BCAA could improve prognosis… read more here.
Keywords: hepatocellular carcinoma; chain amino; branched chain; expression ... See more keywords
A higher bacterial inward BCAA transport driven by Faecalibacterium prausnitzii is associated with lower serum levels of BCAA in early adolescents
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Medicine"
DOI: 10.1186/s10020-021-00371-7
Abstract: Background Elevations of circulating branched-chain amino acids (BCAA) are observed in humans with obesity and metabolic comorbidities, such as insulin resistance. Although it has been described that microbial metabolism contributes to the circulating pool of… read more here.
Keywords: faecalibacterium prausnitzii; early adolescents; bcaa; insulin resistance ... See more keywords