BCAT1 restricts αKG levels in AML stem cells leading to IDHmut-like DNA hypermethylation
Sign Up to like & getrecommendations! Published in 2017 at "Nature"
DOI: 10.1038/nature24294
Abstract: The branched-chain amino acid (BCAA) pathway and high levels of BCAA transaminase 1 (BCAT1) have recently been associated with aggressiveness in several cancer entities. However, the mechanistic role of BCAT1 in this process remains largely… read more here.
Keywords: idhmut; bcat1; dna hypermethylation; stem ... See more keywords
The branched-chain amino acid transaminase 1 sustains growth of antiestrogen-resistant and ERα-negative breast cancer
Sign Up to like & getrecommendations! Published in 2017 at "Oncogene"
DOI: 10.1038/onc.2017.32
Abstract: Antiestrogen-resistant and triple-negative breast tumors pose a serious clinical challenge because of limited treatment options. We assessed global gene expression changes in antiestrogen-sensitive compared with antiestrogen-resistant (two tamoxifen resistant and two fulvestrant resistant) MCF-7 breast… read more here.
Keywords: negative breast; breast; bcat1; antiestrogen resistant ... See more keywords
Loss of BCAT1 Expression is a Sensitive Marker for IDH-Mutant Diffuse Glioma.
Sign Up to like & getrecommendations! Published in 2018 at "Neurosurgery"
DOI: 10.1093/neuros/nyy338
Abstract: BACKGROUND IDH mutation is an important prognostic factor of diffuse astrocytomas. Although the majority of IDH mutations could be identified by immunohistochemical (IHC) stain for R132H-mutant IDH1, DNA sequencing would be required for IHC negative… read more here.
Keywords: diffuse; idh mutations; bcat1; r132h ... See more keywords
PO-395 Mechanistic investigation of epigenetic modifications induced by metabolic changes in AML
Sign Up to like & getrecommendations! Published in 2018 at "ESMO Open"
DOI: 10.1136/esmoopen-2018-eacr25.422
Abstract: Introduction Acute Myeloid Leukaemia is the most common and aggressive adult leukaemia with a high frequency of relapse and mortality. This is likely due to the failure to eliminate the malignant stem like population (LSCs)… read more here.
Keywords: chromatin structure; 395 mechanistic; metabolic changes; bcat1 ... See more keywords
Targeting BCAT1 combined with α-ketoglutarate triggers metabolic synthetic lethality in glioblastoma.
Sign Up to like & getrecommendations! Published in 2022 at "Cancer research"
DOI: 10.1158/0008-5472.can-21-3868
Abstract: Branched-chain amino acid transaminase 1 (BCAT1) is upregulated selectively in human isocitrate dehydrogenase (IDH) wildtype (WT) but not mutant glioblastoma multiforme (GBM) and promotes IDHWT GBM growth. Through a metabolic synthetic lethal screen, we report… read more here.
Keywords: glioblastoma; synthetic lethality; metabolic synthetic; idhwt gbm ... See more keywords
Evaluation of a panel of tumor-specific differentially-methylated DNA regions in IRF4, IKZF1 and BCAT1 for blood-based detection of colorectal cancer
Sign Up to like & getrecommendations! Published in 2021 at "Clinical Epigenetics"
DOI: 10.1186/s13148-020-00999-y
Abstract: Background Differentially-methylated regions (DMRs) are characteristic of colorectal cancer (CRC) and some occur more frequently than common mutations. This study aimed to evaluate the clinical utility of assaying circulating cell-free DNA for methylation in BCAT1,… read more here.
Keywords: detection; bcat1; replicate; differentially methylated ... See more keywords
BCAT1 affects mitochondrial metabolism independently of leucine transamination in activated human macrophages.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of cell science"
DOI: 10.1242/jcs.247957
Abstract: In response to environmental stimuli, macrophages change their nutrient consumption and undergo an early metabolic adaptation that progressively shapes their polarization state. During the transient, early phase of pro-inflammatory macrophage activation, an increase in tricarboxylic… read more here.
Keywords: transamination; bcat1; tca cycle; activation ... See more keywords
LINC00963 Confers Oncogenic Properties in Glioma by Regulating the miR-506/BCAT1 Axis
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Management and Research"
DOI: 10.2147/cmar.s246332
Abstract: Background Glioma is a prevalent disease of the central nervous system with a high incidence and mortality rate. Many long noncoding RNAs (lncRNAs) have been determined to be critical regulators of glioma oncogenesis. However, the… read more here.
Keywords: glioma; linc00963 confers; bcat1; mir 506 ... See more keywords
The BCAT1 CXXC Motif Provides Protection against ROS in Acute Myeloid Leukaemia Cells
Sign Up to like & getrecommendations! Published in 2022 at "Antioxidants"
DOI: 10.3390/antiox11040683
Abstract: The cytosolic branched-chain aminotransferase (BCAT1) has received attention for its role in myeloid leukaemia development, where studies indicate metabolic adaptations due to BCAT1 up-regulation. BCAT1, like the mitochondria isoform (BCAT2), shares a conserved CXXC motif… read more here.
Keywords: cxxc motif; bcat1; bcat1 cxxc; myeloid leukaemia ... See more keywords
Data mining of the expression and regulatory role of BCAT1 in hepatocellular carcinoma
Sign Up to like & getrecommendations! Published in 2019 at "Oncology Letters"
DOI: 10.3892/ol.2019.10932
Abstract: Branched chain amino acid transaminase 1 (BCAT1) catalyzes the production of glutamates and branched-chain α-ketoacids from branched chain amino acids, and a normal BCAT1 expression is associated with tumorigenesis. Sequencing data from public databases, including… read more here.
Keywords: hepatocellular carcinoma; bcat1; analysis; role bcat1 ... See more keywords