BCAT2 Shapes a Noninflamed Tumor Microenvironment and Induces Resistance to Anti‐PD‐1/PD‐L1 Immunotherapy by Negatively Regulating Proinflammatory Chemokines and Anticancer Immunity
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DOI: 10.1002/advs.202207155
Abstract: To improve response rate of monotherapy of immune checkpoint blockade (ICB), it is necessary to find an emerging target in combination therapy. Through analyzing tumor microenvironment (TME)‐related indicators, it is validated that BCAT2 shapes a… read more here.
Keywords: bcat2; immunotherapy; tumor microenvironment; bcat2 shapes ... See more keywords
Acetylation promotes BCAT2 degradation to suppress BCAA catabolism and pancreatic cancer growth
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DOI: 10.1038/s41392-020-0168-0
Abstract: Pancreatic ductal adenocarcinoma (PDAC) is well-known for inefficient early diagnosis, with most patients diagnosed at advanced stages. Increasing evidence indicates that elevated plasma levels of branched-chain amino acids (BCAAs) are associated with an increased risk… read more here.
Keywords: degradation; bcat2; pancreatic cancer; bcaa ... See more keywords
Ruscogenin Alleviates Myocardial Ischemia-Induced Ferroptosis through the Activation of BCAT1/BCAT2
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DOI: 10.3390/antiox11030583
Abstract: Ruscogenin (RUS), a natural steroidal sapogenin, exerts various biological activities. However, its effectiveness for preventing myocardial ischemia (MI) and its molecular mechanisms need further clarification. The model of MI mice and oxygen-glucose deprivation-induced cardiomyocytes injury… read more here.
Keywords: bcat2; bcat1 bcat2; myocardial ischemia; rus ... See more keywords