The BRCA2 and CDKN1A‐interacting protein (BCCIP) stabilizes stalled replication forks and prevents degradation of nascent DNA
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Letters"
DOI: 10.1002/1873-3468.14406
Abstract: DNA replication stress is characterized by impaired replication fork progression, causing some of the replication forks to collapse and form DNA breaks. It is a primary cause of genomic instability leading to oncogenic transformation. The… read more here.
Keywords: bccip; dna; nascent dna; replication ... See more keywords
Structure of human BCCIP and implications for binding and modification of partner proteins
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DOI: 10.1002/pro.4026
Abstract: BCCIP was isolated based on its interactions with tumor suppressors BRCA2 and p21. Knockdown or knockout of BCCIP causes embryonic lethality in mice. BCCIP deficient cells exhibit impaired cell proliferation and chromosome instability. BCCIP also… read more here.
Keywords: bccip; human bccip; partner proteins; structure human ... See more keywords
BCCIP is required for nucleolar recruitment of eIF6 and 12S pre-rRNA production during 60S ribosome biogenesis
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DOI: 10.1093/nar/gkaa1114
Abstract: Abstract Ribosome biogenesis is a fundamental process required for cell proliferation. Although evolutionally conserved, the mammalian ribosome assembly system is more complex than in yeasts. BCCIP was originally identified as a BRCA2 and p21 interacting… read more here.
Keywords: ribosome biogenesis; biogenesis; pre rrna; bccip ... See more keywords
The β-isoform of BCCIP promotes ADP release from the RAD51 presynaptic filament and enhances homologous DNA pairing
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DOI: 10.1093/nar/gkw877
Abstract: Homologous recombination (HR) is a template-driven repair pathway that mends DNA double-stranded breaks (DSBs), and thus helps to maintain genome stability. The RAD51 recombinase facilitates DNA joint formation during HR, but to accomplish this task,… read more here.
Keywords: homologous dna; isoform bccip; bccip; filament ... See more keywords
Inhibition of FAM46/TENT5 activity by BCCIPα adopting a unique fold
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DOI: 10.1126/sciadv.adf5583
Abstract: The FAM46 (also known as TENT5) proteins are noncanonical poly(A) polymerases (PAPs) implicated in regulating RNA stability. The regulatory mechanisms of FAM46 are poorly understood. Here, we report that the nuclear protein BCCIPα, but not… read more here.
Keywords: bccip; unique fold; inhibition fam46; activity ... See more keywords