Can BCG vaccine protect against COVID‐19 via trained immunity and tolerogenesis?
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DOI: 10.1002/bies.202000200
Abstract: As the number of infections and mortalities from the SARS‐CoV‐2 pandemic continues to rise, the development of an effective therapy against COVID‐19 becomes ever more urgent. A few reports showing a positive correlation between BCG… read more here.
Keywords: covid; trained immunity; bcg; immunity tolerogenesis ... See more keywords
TNF, TNF inducers, and TNFR2 agonists: A new path to type 1 diabetes treatment
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DOI: 10.1002/dmrr.2941
Abstract: In the past decade, interest in the century‐old tuberculosis vaccine, bacillus Calmette‐Guerin (BCG), has been revived for potential new therapeutic uses in type 1 diabetes and other forms of autoimmunity. Diverse clinical trials are now… read more here.
Keywords: diabetes treatment; type diabetes; tnf; bcg ... See more keywords
The liposome of trehalose dimycolate extracted from M. bovis BCG induces antitumor immunity via the activation of dendritic cells and CD8+ T cells
Sign Up to like & getrecommendations! Published in 2021 at "Cancer Immunology, Immunotherapy"
DOI: 10.1007/s00262-021-02870-2
Abstract: Intravesical Bovis bacillus Calmette-Guérin (BCG) therapy is the most effective immunotherapy for bladder cancer, but it sometime causes serious side effects because of its inclusion of live bacteria. It is necessary to develop a more… read more here.
Keywords: lip tdm; trehalose dimycolate; tdm; bovis bcg ... See more keywords
The search of new biomarkers in the prediction of BCG response in patients with high-risk NMIBC
Sign Up to like & getrecommendations! Published in 2020 at "World Journal of Urology"
DOI: 10.1007/s00345-020-03195-y
Abstract: Bladder cancer is the sixth leading cause of cancer in the EU with 124,000 people diagnosed and over 40,000 people dying from the disease each year. The estimated total cost of bladder cancer across EU… read more here.
Keywords: response; treatment; search new; bcg response ... See more keywords
COVID-19 and BCG: where’s the challenge?
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DOI: 10.1007/s00345-020-03554-9
Abstract: The COVID-19 pandemic has a huge impact on urological practice. Due to benefit on respiratory infections, Bacillus Calmette–Guerin (BCG) vaccination programs have been proposed to decrease COVID-19 infection severity, and this is due to its… read more here.
Keywords: bcgitis; covid; bcg challenge; covid bcg ... See more keywords
Immediate radical cystectomy versus BCG immunotherapy for T1 high-grade non-muscle-invasive squamous bladder cancer: an international multi-centre collaboration
Sign Up to like & getrecommendations! Published in 2022 at "World Journal of Urology"
DOI: 10.1007/s00345-022-03958-9
Abstract: To compare cancer-specific mortality (CSM) and overall mortality (OM) between immediate radical cystectomy (RC) and Bacillus Calmette–Guérin (BCG) immunotherapy for T1 squamous bladder cancer (BCa). We retrospectively analysed 188 T1 high-grade squamous BCa patients treated… read more here.
Keywords: cancer; immediate radical; bladder; bcg immunotherapy ... See more keywords
Content of the Major Extracellular Matrix Components of the Liver and Lungs in Mice with Chronic BCG-Granulomatosis Treated with Liposome-Encapsulated Dextrazide.
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DOI: 10.1007/s10517-021-05086-7
Abstract: Administration of the liposome-encapsulated dextrazide (LEDZ) to mice 6 months after infection with mycobacterium BCG vaccine for 3 months modulated metabolism of collagens and the intensity of fibrosis of internal organs. In the liver, we… read more here.
Keywords: major extracellular; content major; encapsulated dextrazide; content ... See more keywords
Nuclear co-expression of p21 and p27 induced effective cell-cycle arrest in T24 cells treated with BCG
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DOI: 10.1007/s10616-018-0278-5
Abstract: A proposed mechanism underlying the effect of bacillus Calmette–Guérin (BCG) treatment for bladder cancer cells is as follows: BCG-induced crosslinking of cell-surface receptors results in the activation of signaling cascades, including cell-cycle regulators. However, the… read more here.
Keywords: p21 p27; nuclear expression; bcg; p27 ... See more keywords
Autosomal Dominant IFN-γR1 Deficiency Presenting with both Atypical Mycobacteriosis and Tuberculosis in a BCG-Vaccinated South African Patient
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Immunology"
DOI: 10.1007/s10875-018-0509-8
Abstract: To the Editor, Mendelian susceptibility to mycobacterial disease (MSMD) refers to a group of primary immunodeficiency disorders (PIDs) that characteristically cause susceptibility to mycobacterial infections by a range of mycobacteria and to systemic nontyphoidal salmonellosis… read more here.
Keywords: ifn deficiency; dominant ifn; autosomal dominant; msmd ... See more keywords
BCG Moreau Vaccine Safety Profile and NK Cells—Double Protection Against Disseminated BCG Infection in Retrospective Study of BCG Vaccination in 52 Polish Children with Severe Combined Immunodeficiency
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Clinical Immunology"
DOI: 10.1007/s10875-019-00709-1
Abstract: Objectives The aim of the study was to estimate the rate of adverse reactions to live BCG Moreau vaccine, manufactured by Biomed in Poland, in severe combined immunodeficiency (SCID) patients. Material The profiles of 52… read more here.
Keywords: disseminated bcg; study; moreau vaccine; scid patients ... See more keywords
Discovery of the first macrolide antibiotic binding protein in Mycobacterium tuberculosis: a new antibiotic resistance drug target
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DOI: 10.1007/s13238-017-0502-7
Abstract: The prevalence of multidrug-resistant Mycobacterium tuberculosis (M. tuberculosis) is an increasing problem worldwide (Zumla et al., 2013; Dong et al., 2015). According to a 2014 World Health Organization (WHO) report, 480,000 individuals world-wide developed multidrug-resistant… read more here.
Keywords: rv3197; target; drug; tuberculosis ... See more keywords