Childhood Bacille Calmette-Guerin Vaccination and Its Association With Less Severe COVID-19 Pneumonia
Sign Up to like & getrecommendations! Published in 2021 at "American Journal of Preventive Medicine"
DOI: 10.1016/j.amepre.2021.02.025
Abstract: Introduction The potential for bacillus Calmette–Guérin (BCG) vaccination to mitigate coronavirus disease 2019 (COVID-19) severity and perhaps infection susceptibility has been hypothesized, attracting global attention given its off-target benefits demonstrated in several respiratory viral infections.… read more here.
Keywords: less severe; bcg vaccination; vaccination; severe covid ... See more keywords
BCG Vaccination Induces Long-Term Functional Reprogramming of Human Neutrophils
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DOI: 10.1016/j.celrep.2020.108387
Abstract: Summary The tuberculosis vaccine bacillus Calmette-Guérin (BCG) protects against some heterologous infections, probably via induction of non-specific innate immune memory in monocytes and natural killer (NK) cells, a process known as trained immunity. Recent studies… read more here.
Keywords: bcg vaccination; induces long; human neutrophils; vaccination ... See more keywords
BCG vaccination provides protection against IAV but not SARS-CoV-2
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DOI: 10.1016/j.celrep.2022.110502
Abstract: Since the vast majority of species solely rely on innate immunity for host defense, it stands to reason that a critical evolutionary trait like immunological memory evolved in this primitive branch of our immune system.… read more here.
Keywords: iav sars; bcg vaccination; sars cov;
The effect of BCG vaccination on alveolar macrophages obtained from induced sputum from healthy volunteers.
Sign Up to like & getrecommendations! Published in 2020 at "Cytokine"
DOI: 10.1016/j.cyto.2020.155135
Abstract: The anti-tuberculosis vaccine Bacillus Calmette-Guérin (BCG) is able to boost innate immune responses through a process called 'trained immunity'. It is hypothesized that BCG-induced trained immunity contributes to protection against Mycobacterium tuberculosis infection. Since alveolar… read more here.
Keywords: vaccination alveolar; alveolar macrophages; bcg vaccination; induced sputum ... See more keywords
Effectiveness of bacillus Calmette–Guerin vaccination history on pulmonary tuberculosis symptoms
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DOI: 10.1016/j.jctube.2019.100126
Abstract: Introduction The aim of this study was to explore the effectiveness of BCG vaccination on the severity of clinical symptoms of pulmonary tuberculosis symptoms (PTb) in patients from the northwest and west of Iran. Materials… read more here.
Keywords: bcg vaccination; study; clinical symptoms; tuberculosis ... See more keywords
Impact of individual-level factors on Ex vivo mycobacterial growth inhibition: Associations of immune cell phenotype, cytomegalovirus-specific response and sex with immunity following BCG vaccination in humans.
Sign Up to like & getrecommendations! Published in 2019 at "Tuberculosis"
DOI: 10.1016/j.tube.2019.101876
Abstract: Understanding factors associated with varying efficacy of Bacillus Calmette-Guérin (BCG) would aid the development of improved vaccines against tuberculosis (TB). In addition, investigation of individual-level factors affecting mycobacterial-specific immune responses could provide insight into confounders… read more here.
Keywords: bcg vaccination; cell; growth inhibition; mycobacterial growth ... See more keywords
In-vivo expressed Mycobacterium tuberculosis antigens recognised in three mouse strains after infection and BCG vaccination
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DOI: 10.1038/s41541-021-00343-2
Abstract: Novel tuberculosis (TB)-vaccines preferably should (i) boost host immune responses induced by previous BCG vaccination and (ii) be directed against Mycobacterium tuberculosis ( Mtb ) proteins expressed throughout the Mtb infection-cycle. Human Mtb antigen-discovery screens… read more here.
Keywords: tuberculosis; bcg vaccination; infection; antigens recognised ... See more keywords
BCG vaccination for type 1 diabetes mellitus
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DOI: 10.1038/s41574-018-0064-7
Abstract: and enrolled additional patients with T1DM who had received the BCG vaccine,” explains Faustman. In the current study, 52 participants with T1DM received standard care or standard care with either BCG vaccine or placebo. The… read more here.
Keywords: bcg vaccination; type diabetes; standard care; vaccination type ... See more keywords
Health economic evaluation of current vaccination strategies and new vaccines against tuberculosis: a systematic review
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DOI: 10.1080/14760584.2019.1651650
Abstract: ABSTRACT Introduction: Bacillus Calmette-Guérin (BCG) is the only licensed vaccine for tuberculosis, but its effectiveness is limited and varies by age. New candidate vaccines are currently being investigated. In response to the declining incidence of… read more here.
Keywords: health economic; bcg vaccination; tuberculosis; vaccination strategies ... See more keywords
Local Tuberculosis Georeference: a tool to define BCG vaccination in high-incidence area in Portugal
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Public Health"
DOI: 10.1093/eurpub/ckz186.532
Abstract: Tuberculosis (TB) incidence in Portugal is < 20/100000 people, with high-incidence municipalities in urban areas such as Amadora. In 2016, the national vaccination programme moved the BCG vaccine from universal to restricted risk groups. Amadora,… read more here.
Keywords: incidence; bcg vaccination; high incidence; incidence area ... See more keywords
Cyclic di-AMP-mediated interaction between Mycobacterium tuberculosis &Dgr;cnpB and macrophages implicates a novel strategy for improving BCG vaccination
Sign Up to like & getrecommendations! Published in 2018 at "Pathogens and Disease"
DOI: 10.1093/femspd/fty008
Abstract: Cyclic di-AMP (c-di-AMP) has been shown to play an important role in bacterial physiology and pathogen-host interactions. We previously reported that deletion of the sole c-di-AMP phosphodiesterase-encoding gene (cnpB) in Mycobacterium tuberculosis (Mtb) led to… read more here.
Keywords: bcg vaccination; cyclic amp; amp; cnpb ... See more keywords