Synthesis and Hybrid SAR Property Modeling of Novel Cholinesterase Inhibitors †
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DOI: 10.3390/ijms22073444
Abstract: A library of novel 4-{[(benzyloxy)carbonyl]amino}-2-hydroxybenzoic acid amides was designed and synthesized in order to provide potential acetyl- and butyrylcholinesterase (AChE/BChE) inhibitors; the in vitro inhibitory profile and selectivity index were specified. Benzyl(3-hydroxy-4-{[2-(trifluoromethoxy)phenyl]carbamoyl}phenyl)carbamate was the best… read more here.
Keywords: ache; ache bche; bche inhibitors; synthesis hybrid ... See more keywords