Bcl‐2 inhibitors enhance FGFR inhibitor‐induced mitochondrial‐dependent cell death in FGFR2‐mutant endometrial cancer
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Oncology"
DOI: 10.1002/1878-0261.12422
Abstract: Endometrial cancer is the most commonly diagnosed gynaecological malignancy. Unfortunately, 15–20% of women demonstrate persistent or recurrent tumours that are refractory to current chemotherapies. We previously identified activating mutations in fibroblast growth factor receptor 2… read more here.
Keywords: bcl; death; endometrial cancer; cell death ... See more keywords
JAK-STAT signaling shapes the NF-κB response in CLL towards venetoclax sensitivity or resistance via Bcl-XL.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular oncology"
DOI: 10.1002/1878-0261.13364
Abstract: Preventing or overcoming resistance to the Bcl‐2 inhibitor venetoclax is an emerging unmet clinical need in patients with chronic lymphocytic leukaemia (CLL). The upregulation of anti‐apoptotic Bcl‐2 members through signalling pathways within the tumor microenvironment… read more here.
Keywords: sensitivity; resistance; cll; jak stat ... See more keywords
Coordination-Driven Self-Assembly of Biomedicine to Enhance Photodynamic Therapy by Inhibiting Proteasome and Bcl-2.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202300711
Abstract: Tumor cells resist oxidative damage and apoptosis by activating defense mechanisms. Herein, a self-delivery biomedicine (designated as BSC) is developed by the self-assembly of Bortezomib (BTZ), Sabutoclax (Sab) and Chlorin e6 (Ce6). Interestingly, BTZ can… read more here.
Keywords: self assembly; coordination driven; photodynamic therapy; proteasome bcl ... See more keywords
Bcl‐2/Bcl‐xl inhibitor APG‐1252‐M1 is a promising therapeutic strategy for gastric carcinoma
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Medicine"
DOI: 10.1002/cam4.3090
Abstract: Gastric carcinoma is the third major cause of cancer‐related death in China. Bcl‐2 and other BH3 family proteins are critically important in the process of apoptosis pathway, which may be a promising target. APG‐1252‐M1 specifically… read more here.
Keywords: gastric carcinoma; antitumor effect; bcl bcl; apg 1252 ... See more keywords
Strategies to Reduce the On‐Target Platelet Toxicity of Bcl‐xL Inhibitors: PROTACs, SNIPERs and Prodrug‐Based Approaches
Sign Up to like & getrecommendations! Published in 2022 at "Chembiochem"
DOI: 10.1002/cbic.202100689
Abstract: Apoptosis is a highly regulated cellular process. Aberration in apoptosis is a common characteristic of various disorders. Therefore, proteins involved in apoptosis are prime targets in multiple therapies. Bcl‐xL is an antiapoptotic protein. Compared to… read more here.
Keywords: pharmacology; based approaches; bcl; target platelet ... See more keywords
Effect of UV Stress on the Structure and Function of Pro‐apoptotic Bid and Anti‐apoptotic Bcl‐xl proteins
Sign Up to like & getrecommendations! Published in 2023 at "ChemBioChem"
DOI: 10.1002/cbic.202200682
Abstract: Ultraviolet C (UV‐C) radiation induces apoptosis in mammalian cells via the mitochondrion‐mediated pathway. The Bcl‐2 family of proteins are the regulators of the mitochondrial pathway of apoptosis and appears responsive to UV‐C radiation. It is… read more here.
Keywords: pro apoptotic; structure function; function pro; bid ... See more keywords
Triple combination targeting methyltransferase, BCL‐2, and PD‐1 facilitates antileukemia responses in acute myeloid leukemia
Sign Up to like & getrecommendations! Published in 2022 at "Cancer"
DOI: 10.1002/cncr.34566
Abstract: A recent breakthrough therapy combining the BCL‐2 inhibitor venetoclax with hypomethylating agents (HMAs) targeting DNA methyltransferase has improved outcomes for patients with acute myeloid leukemia (AML), but the responses and long‐term survival in older/unfit patients… read more here.
Keywords: myeloid leukemia; triple combination; acute myeloid; methyltransferase ... See more keywords
Evaluating the inhibitory priority of Bcl‐xL to Bad, tBid and Bax by using live‐cell imaging assay
Sign Up to like & getrecommendations! Published in 2021 at "Cytometry Part A"
DOI: 10.1002/cyto.a.24351
Abstract: Molecular regulatory network among the B cell leukemia‐2 (Bcl‐2) family proteins is a research hotspot on apoptosis. The inhibitory priority of anti‐apoptotic Bcl‐2 family proteins (such as Bcl‐xL) to pro‐apoptotic Bcl‐2 family proteins (such as… read more here.
Keywords: bad tbid; tbid bax; tbid; bcl ... See more keywords
Diallyl trisulfide plays an antifibrotic role by inhibiting the expression of Bcl‐2 in hepatic stellate cells
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.23097
Abstract: Hepatic fibrosis is an important early stage in the evolution of liver cirrhosis, and specific medicine and therapeutic measures are unavailable to date. Hepatic stellate cells (HSCs) are the main cells involved in the formation… read more here.
Keywords: stellate cells; hepatic fibrosis; hepatic stellate; fibrosis ... See more keywords
Therapeutic potential of the novel Bcl‐2/Bcl‐XL dual inhibitor, APG1252, alone or in combination against non‐small cell lung cancer
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Carcinogenesis"
DOI: 10.1002/mc.23458
Abstract: Targeting the induction of apoptosis is a promising cancer therapeutic strategy with some clinical success. This study focused on evaluating the therapeutic efficacy of the novel Bcl‐2/Bcl‐XL dual inhibitor, APG1252‐M1 (also named APG‐1244; an in… read more here.
Keywords: cell; novel bcl; combination; inhibitor ... See more keywords
Hsa_circ_0088036 promotes nonsmall cell lung cancer progression by regulating miR-1343-3p/Bcl-3 axis through TGFβ/Smad3/EMT signaling.
Sign Up to like & getrecommendations! Published in 2023 at "Molecular carcinogenesis"
DOI: 10.1002/mc.23547
Abstract: Nonsmall cell lung cancer (NSCLC) is the leading cause of cancer-related mortality worldwide. Circular RNAs (circRNAs) have been the focus of numerous studies, and some circRNAs have been linked to the development of multiple malignant… read more here.
Keywords: mir 1343; hsa circ; bcl; circ 0088036 ... See more keywords