Bcl‐2/Bcl‐xl inhibitor APG‐1252‐M1 is a promising therapeutic strategy for gastric carcinoma
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DOI: 10.1002/cam4.3090
Abstract: Gastric carcinoma is the third major cause of cancer‐related death in China. Bcl‐2 and other BH3 family proteins are critically important in the process of apoptosis pathway, which may be a promising target. APG‐1252‐M1 specifically… read more here.
Keywords: gastric carcinoma; antitumor effect; bcl bcl; apg 1252 ... See more keywords
Secretin Prevents Apoptosis in the Developing Cerebellum Through Bcl-2 and Bcl-xL
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Molecular Neuroscience"
DOI: 10.1007/s12031-019-01287-y
Abstract: Secretin (SCT) is involved in a variety of physiological processes and has been implicated in preventing apoptosis during brain development. However, little is known about the molecular mechanism underlying its neuroprotective effects. The B cell… read more here.
Keywords: developing cerebellum; bcl bcl; sct; bcl ... See more keywords
Targeting BCL-W and BCL-XL as a therapeutic strategy for Hodgkin lymphoma
Sign Up to like & getrecommendations! Published in 2019 at "Leukemia"
DOI: 10.1038/s41375-019-0611-9
Abstract: Hodgkin lymphoma (HL), accounting for ~10% of lymphomas diagnosed in the United States (1), have a largely favorable outcome (5-year survival 85%) that may be improved with anti-CD30-drug conjugates or checkpoint inhibitors (2, 3). However,… read more here.
Keywords: bcl bcl; targeting bcl; hodgkin lymphoma; hodgkin ... See more keywords
Abstract 307: Targeting BCL-2 and BCL-xL with a novel dual inhibitor APG-1252 triggers cell death and inhibits tumor growth in small cell lung cancer models
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-307
Abstract: Small cell lung cancer (SCLC) is one of the most deadly diseases with a dismal five year survival rate less than 7%. Even though most SCLC patients respond to the initial platinum-based cytotoxic or radiation… read more here.
Keywords: bcl bcl; apg 1252; cancer; bcl ... See more keywords
Sensitivity of Cutaneous T-Cell Lymphoma Cells to the Mcl-1 Inhibitor S63845 Correlates with the Lack of Bcl-w Expression
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232012471
Abstract: Long-term, curative treatment of cutaneous T-cell lymphomas (CTCL) remains a major challenge. Therapy resistance is often based on apoptosis deficiency, and may depend on antiapoptotic Bcl-2 proteins, such as Bcl-2, Bcl-xL, Bcl-w and Mcl-1. For… read more here.
Keywords: cell; bcl bcl; expression; s63845 ... See more keywords
Bcl-XL but Not Bcl-2 Is a Potential Target in Medulloblastoma Therapy
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DOI: 10.3390/ph15010091
Abstract: Medulloblastoma (MB) is the most common solid tumour in children and, despite current treatment with a rather aggressive combination therapy, accounts for 10% of all deaths associated with paediatric cancer. Breaking the tumour cells’ intrinsic… read more here.
Keywords: cell death; abt 263; bcl bcl; therapy ... See more keywords