Bcl‐2/Bcl‐xl inhibitor APG‐1252‐M1 is a promising therapeutic strategy for gastric carcinoma
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Medicine"
DOI: 10.1002/cam4.3090
Abstract: Gastric carcinoma is the third major cause of cancer‐related death in China. Bcl‐2 and other BH3 family proteins are critically important in the process of apoptosis pathway, which may be a promising target. APG‐1252‐M1 specifically… read more here.
Keywords: gastric carcinoma; antitumor effect; bcl bcl; apg 1252 ... See more keywords
Fisetin Clears Senescent Cells Through the Pi3k‐Akt‐Bcl‐2/Bcl‐xl Pathway to Alleviate Diabetic Aortic Aging
Sign Up to like & getrecommendations! Published in 2025 at "Phytotherapy Research"
DOI: 10.1002/ptr.8507
Abstract: Vascular aging is a major contributor to age‐related cardiovascular diseases (CVDs) and type 2 diabetes mellitus (T2DM) induced early arterial aging and excessive senescent cells (SCs) burden in vessels. Inhibiting cellular senescence or eliminating SCs… read more here.
Keywords: senescent cells; bcl bcl; aortic aging; fisetin ... See more keywords
Secretin Prevents Apoptosis in the Developing Cerebellum Through Bcl-2 and Bcl-xL
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Molecular Neuroscience"
DOI: 10.1007/s12031-019-01287-y
Abstract: Secretin (SCT) is involved in a variety of physiological processes and has been implicated in preventing apoptosis during brain development. However, little is known about the molecular mechanism underlying its neuroprotective effects. The B cell… read more here.
Keywords: developing cerebellum; bcl bcl; sct; bcl ... See more keywords
Targeting BCL-W and BCL-XL as a therapeutic strategy for Hodgkin lymphoma
Sign Up to like & getrecommendations! Published in 2019 at "Leukemia"
DOI: 10.1038/s41375-019-0611-9
Abstract: Hodgkin lymphoma (HL), accounting for ~10% of lymphomas diagnosed in the United States (1), have a largely favorable outcome (5-year survival 85%) that may be improved with anti-CD30-drug conjugates or checkpoint inhibitors (2, 3). However,… read more here.
Keywords: bcl bcl; targeting bcl; hodgkin lymphoma; hodgkin ... See more keywords
Cyclic peptides discriminate BCL-2 and its clinical mutants from BCL-XL by engaging a single-residue discrepancy
Sign Up to like & getrecommendations! Published in 2024 at "Nature Communications"
DOI: 10.1038/s41467-024-45848-1
Abstract: Overexpressed pro-survival B-cell lymphoma-2 (BCL-2) family proteins BCL-2 and BCL-XL can render tumor cells malignant. Leukemia drug venetoclax is currently the only approved selective BCL-2 inhibitor. However, its application has led to an emergence of… read more here.
Keywords: single residue; bcl bcl; bcl; cyclic peptides ... See more keywords
Development and crystal structures of a potent second-generation dual degrader of BCL-2 and BCL-xL
Sign Up to like & getrecommendations! Published in 2024 at "Nature Communications"
DOI: 10.1038/s41467-024-46922-4
Abstract: Overexpression of BCL-xL and BCL-2 play key roles in tumorigenesis and cancer drug resistance. Advances in PROTAC technology facilitated recent development of the first BCL-xL/BCL-2 dual degrader, 753b, a VHL-based degrader with improved potency and… read more here.
Keywords: bcl bcl; bcl; dual degrader; development ... See more keywords
Relative importance of the anti-apoptotic versus apoptosis-unrelated functions of MCL-1 in vivo.
Sign Up to like & getrecommendations! Published in 2025 at "Science"
DOI: 10.1126/science.adw1836
Abstract: The anti-apoptotic protein MCL-1 (myeloid cell leukemia-1) is essential for embryogenesis and the survival of many cell types that tolerate loss of its relatives, BCL-XL and BCL-2. Apoptosis-unrelated roles of MCL-1 in metabolism may contribute… read more here.
Keywords: anti apoptotic; unrelated functions; bcl bcl; bcl ... See more keywords
Abstract 307: Targeting BCL-2 and BCL-xL with a novel dual inhibitor APG-1252 triggers cell death and inhibits tumor growth in small cell lung cancer models
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-307
Abstract: Small cell lung cancer (SCLC) is one of the most deadly diseases with a dismal five year survival rate less than 7%. Even though most SCLC patients respond to the initial platinum-based cytotoxic or radiation… read more here.
Keywords: bcl bcl; apg 1252; cancer; bcl ... See more keywords
Sensitivity of Cutaneous T-Cell Lymphoma Cells to the Mcl-1 Inhibitor S63845 Correlates with the Lack of Bcl-w Expression
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232012471
Abstract: Long-term, curative treatment of cutaneous T-cell lymphomas (CTCL) remains a major challenge. Therapy resistance is often based on apoptosis deficiency, and may depend on antiapoptotic Bcl-2 proteins, such as Bcl-2, Bcl-xL, Bcl-w and Mcl-1. For… read more here.
Keywords: cell; bcl bcl; expression; s63845 ... See more keywords
A First-in-Class Dual Degrader of Bcl-2/Bcl-xL Reverses HIV Latency and Minimizes Ex Vivo Reservoirs from Patients
Sign Up to like & getrecommendations! Published in 2025 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms26062772
Abstract: The persistence of latent HIV-1 proviruses in CD4+ T cells is a major obstacle to curing HIV. The “shock and kill” strategy involves reversing latency with latency-reversing agents (LRAs) and selectively inducing cell death in… read more here.
Keywords: hiv; bcl bcl; bcl; latency ... See more keywords
Bcl-XL but Not Bcl-2 Is a Potential Target in Medulloblastoma Therapy
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceuticals"
DOI: 10.3390/ph15010091
Abstract: Medulloblastoma (MB) is the most common solid tumour in children and, despite current treatment with a rather aggressive combination therapy, accounts for 10% of all deaths associated with paediatric cancer. Breaking the tumour cells’ intrinsic… read more here.
Keywords: cell death; abt 263; bcl bcl; therapy ... See more keywords