Dexpanthenol exhibits antiapoptotic and anti‐inflammatory effects against nicotine‐induced liver damage by modulating Bax/Bcl‐xL, Caspase‐3/9, and Akt/NF‐κB pathways
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DOI: 10.1002/jbt.23622
Abstract: Chronic tobacco use can lead to liver damage and inflammation due to the accumulation of various toxins in the body. This study aimed to investigate the correlation between the molecular mechanisms of nicotine‐induced liver injury,… read more here.
Keywords: bcl caspase; nicotine induced; bax bcl; caspase ... See more keywords
Homoharringtonine regulates the alternative splicing of Bcl-x and caspase 9 through a protein phosphatase 1-dependent mechanism
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DOI: 10.1186/s12906-018-2233-6
Abstract: BackgroundHomoharringtonine (HHT) is a natural alkaloid with potent antitumor activity, but its precise mechanism of action is still poorly understood.MethodsWe examined the effect of HHT on alternative splicing of Bcl-x and Caspase 9 in various… read more here.
Keywords: caspase; bcl caspase; mechanism; splicing bcl ... See more keywords
Asiaticoside Prevents Oxidative Stress and Apoptosis in Endothelial Cells by Activating ROS-dependent p53/Bcl-2/Caspase-3 Signaling Pathway.
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DOI: 10.2174/1566524023666221024120825
Abstract: BACKGROUND Asiaticoside (AC) is a triterpenoid saponin found in Centella asiatica (L.) Urban extract that has a wide range of pharmacological properties. Our previous study demonstrated that AC could promote angiogenesis in diabetic wounds, but… read more here.
Keywords: bcl caspase; apoptosis; endothelial cells; p53 ... See more keywords