Apoptotic mitochondrial poration by a growing list of pore‐forming BCL‐2 family proteins
Sign Up to like & getrecommendations! Published in 2023 at "BioEssays"
DOI: 10.1002/bies.202200221
Abstract: The pore‐forming BCL‐2 family proteins are effectors of mitochondrial poration in apoptosis initiation. Two atypical effectors—BOK and truncated BID (tBID)—join the canonical effectors BAK and BAX. Gene knockout revealed developmental phenotypes in the absence the… read more here.
Keywords: bcl family; pore forming; mitochondrial poration; forming bcl ... See more keywords
Reconstitution and Characterization of BCL-2 Family Proteins in Lipid Bilayer Nanodiscs.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-8861-7_16
Abstract: The BCL-2 family proteins are key regulators of programmed cell death or apoptosis, and represent important targets for the development of anticancer drugs. Because their functions are intimately connected with intracellular membranes, it is important… read more here.
Keywords: bilayer nanodiscs; bcl family; family; lipid bilayer ... See more keywords
Database and Bioinformatic Analysis of BCL-2 Family Proteins and BH3-Only Proteins.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-8861-7_2
Abstract: BCL-2 proteins correspond to a structurally, functionally, and phylogenetically heterogeneous group of regulators that play crucial roles in the life and death of animal cells. Some of these regulators also represent therapeutic targets in human… read more here.
Keywords: bh3 proteins; database bioinformatic; analysis; analysis bcl ... See more keywords
Photocrosslinking Approach to Investigate Protein Interactions in the BCL-2 Family.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-8861-7_9
Abstract: The Bcl-2 family of proteins regulates mitochondrial outer membrane permeability thereby making life or death decisions for cells. Most of Bcl-2 proteins contain hydrophobic regions that are embedded in intracellular membranes such as mitochondria. These… read more here.
Keywords: photocrosslinking approach; interactions bcl; bcl proteins; bcl family ... See more keywords
Bcl-2 family proteins, beyond the veil.
Sign Up to like & getrecommendations! Published in 2020 at "International review of cell and molecular biology"
DOI: 10.1016/bs.ircmb.2019.12.001
Abstract: Apoptosis is an important part of both health and disease and is often regulated by the BCL-2 family of proteins. These proteins are either pro- or anti-apoptotic, existing in a delicate balance during homeostasis. They… read more here.
Keywords: bcl family; family; family proteins; proteins beyond ... See more keywords
Bcl-xL and IP3R interaction: Intimate relationship with an uncertain outcome.
Sign Up to like & getrecommendations! Published in 2021 at "Cell calcium"
DOI: 10.1016/j.ceca.2021.102504
Abstract: Bcl-2 family proteins are major apoptosis regulators. They control a key step in apoptosis execution referred to as the mitochondrial outer membrane permeabilization. Several Bcl-2 homologs were also reported to act at the level of… read more here.
Keywords: ip3r interaction; intimate relationship; bcl ip3r; bcl family ... See more keywords
Expanding the Cancer Arsenal with Targeted Therapies: Disarmament of the Antiapoptotic Bcl-2 Proteins by Small Molecules.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.5b01888
Abstract: A hallmark of cancer is the evasion of apoptosis, which is often associated with the upregulation of the antiapoptotic members of the Bcl-2 family of proteins. The prosurvival function of the antiapoptotic Bcl-2 proteins is… read more here.
Keywords: bcl proteins; bcl family; antiapoptotic bcl; bcl ... See more keywords
BCL-2 family proteins: changing partners in the dance towards death
Sign Up to like & getrecommendations! Published in 2018 at "Cell Death and Differentiation"
DOI: 10.1038/cdd.2017.186
Abstract: The BCL-2 family of proteins controls cell death primarily by direct binding interactions that regulate mitochondrial outer membrane permeabilization (MOMP) leading to the irreversible release of intermembrane space proteins, subsequent caspase activation and apoptosis. The… read more here.
Keywords: death; bcl family; family; proteins changing ... See more keywords
From basic apoptosis discoveries to advanced selective BCL-2 family inhibitors
Sign Up to like & getrecommendations! Published in 2017 at "Nature Reviews Drug Discovery"
DOI: 10.1038/nrd.2016.253
Abstract: Members of the B cell lymphoma 2 (BCL-2) gene family have a central role in regulating programmed cell death by controlling pro-apoptotic and anti-apoptotic intracellular signals. In cancer, apoptosis evasion through dysregulation of specific BCL-2… read more here.
Keywords: apoptosis; bcl family; family; selective bcl ... See more keywords
Neuronal cell life, death, and axonal degeneration as regulated by the BCL-2 family proteins
Sign Up to like & getrecommendations! Published in 2020 at "Cell Death and Differentiation"
DOI: 10.1038/s41418-020-00654-2
Abstract: Axonal degeneration and neuronal cell death are fundamental processes in development and contribute to the pathology of neurological disease in adults. Both processes are regulated by BCL-2 family proteins which orchestrate the permeabilization of the… read more here.
Keywords: neuronal cell; death; degeneration; bcl family ... See more keywords
Systematic mapping of BCL-2 gene dependencies in cancer reveals molecular determinants of BH3 mimetic sensitivity
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-05815-z
Abstract: While inhibitors of BCL-2 family proteins (BH3 mimetics) have shown promise as anti-cancer agents, the various dependencies or co-dependencies of diverse cancers on BCL-2 genes remain poorly understood. Here we develop a drug screening approach… read more here.
Keywords: cancer; bcl; bcl family; mimetic sensitivity ... See more keywords