Proteome‐Wide Identification of On‐ and Off‐Targets of Bcl‐2 Inhibitors in Native Biological Systems by Using Affinity‐Based Probes (AfBPs)
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DOI: 10.1002/cbic.201800380
Abstract: Selective inhibition of proteins of the Bcl‐2 family by small‐molecule inhibitors is a promising new approach in drug discovery. However, information about how these molecules interact with their cellular targets (on‐ and off‐) is highly… read more here.
Keywords: probes afbps; targets bcl; bcl inhibitors; affinity based ... See more keywords
Drugs and Clinical Approaches Targeting the Antiapoptotic Protein: A Review
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DOI: 10.1155/2019/1212369
Abstract: B-cell lymphoma 2 (Bcl-2) is a regulator protein involved in apoptosis. In the past few decades, this protein has been demonstrated to have high efficacy in cancer therapy, and several approaches targeting Bcl-2 have been… read more here.
Keywords: protein; approaches targeting; bcl inhibitors; review ... See more keywords
Abstract 6161: Targeting endogenous and therapy-induced dependence on BCL-XL in high grade serous ovarian carcinoma
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DOI: 10.1158/1538-7445.am2023-6161
Abstract: Though most patients diagnosed with high-grade serous ovarian carcinoma (HGSOC) have favorable initial responses to therapy, approximately 80% will experience tumor recurrence and develop chemoresistant disease. This highlights the urgent need for more effective therapeutic… read more here.
Keywords: high grade; hgsoc; therapy; bcl inhibitors ... See more keywords