Development of venetoclax performance using its new derivatives on BCL‐2 protein inhibition
Sign Up to like & getrecommendations! Published in 2022 at "Cell Biochemistry and Function"
DOI: 10.1002/cbf.3760
Abstract: Cancer cells are resistant to apoptosis and this is one of the most obvious symptoms of cancer in humans. One of the most exciting strategies for treating cancer is to design regulators that increase cell… read more here.
Keywords: performance using; performance; using new; venetoclax performance ... See more keywords
Discovery and development of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid derivatives as Bcl-2/Mcl-1 inhibitors.
Sign Up to like & getrecommendations! Published in 2019 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2019.102938
Abstract: Bcl-2 family proteins play a vital role for cancer cell in escaping apoptosis, and small-molecule anti-apoptotic Bcl-2 protein inhibitors have been developed as new anticancer therapies. In current study, a series of substituted 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid… read more here.
Keywords: bcl protein; carboxylic acid; tetrahydroisoquinoline carboxylic; acid derivatives ... See more keywords
Potential applications of BPFP1 in Bcl-2 protein quantification, carcinoma cell visualization, cell sorting and early cancer diagnosis.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2021.113725
Abstract: Overexpression of the Bcl-2 protein has emerged as a hallmark of carcinoma cells and can be employed as a biochemical biomarker of these cells. Therefore, some Bcl-2 protein fluorescence probes (BPFPs) were designed for Bcl-2… read more here.
Keywords: protein; bcl protein; cell; carcinoma cells ... See more keywords
Bcl-2 protein family expression pattern determines synergistic pro-apoptotic effects of BH3 mimetics with hemisynthetic cardiac glycoside UNBS1450 in acute myeloid leukemia
Sign Up to like & getrecommendations! Published in 2017 at "Leukemia"
DOI: 10.1038/leu.2016.341
Abstract: Bcl-2 protein family expression pattern determines synergistic pro-apoptotic effects of BH3 mimetics with hemisynthetic cardiac glycoside UNBS1450 in acute myeloid leukemia read more here.
Keywords: bcl protein; protein family; pattern determines; family expression ... See more keywords
Effect of Promising Antitumor Phenolic Antioxidant Anphen Sodium on the BCL-2 Family Proteins
Sign Up to like & getrecommendations! Published in 2018 at "Doklady Biochemistry and Biophysics"
DOI: 10.1134/s1607672918050101
Abstract: The proapoptotic effect of anphen (the effect on the level of the antiapoptotic protein Bcl-2) was investigated by immunoblotting. Incubation of Lewis carcinoma cell suspension with anphen at a concentration of 10–6 M for 0–3… read more here.
Keywords: effect; anphen; antitumor; bcl protein ... See more keywords
Bcl-2 Protein Targeting by the p53/p21 Complex-Response.
Sign Up to like & getrecommendations! Published in 2018 at "Cancer research"
DOI: 10.1158/0008-5472.can-17-3919
Abstract: We thank Hernandez Borrero and colleagues for their comments ([1][1]) on our article ([2][2]), especially their consideration of novel paradigm-shifting aspects. As they requested, we have presented coimmunoprecipitation data showing endogenous p53–p21 protein interaction in… read more here.
Keywords: p53 p21; bcl protein; protein targeting; p53 ... See more keywords
BH4-mimetics and -antagonists: an emerging class of Bcl-2 protein modulators for cancer therapy
Sign Up to like & getrecommendations! Published in 2018 at "Oncotarget"
DOI: 10.18632/oncotarget.26250
Abstract: Dysregulation of cell death pathways is a hallmark of cancer progression. Hence pharmacological intervention to restore the apoptotic balance in tumors is considered to be a major objective for current cancer treatment strategies. At the… read more here.
Keywords: bh4; pro survival; bcl protein; therapy ... See more keywords
In Silico Mining of Natural Products Atlas (NPAtlas) Database for Identifying Effective Bcl-2 Inhibitors: Molecular Docking, Molecular Dynamics, and Pharmacokinetics Characteristics
Sign Up to like & getrecommendations! Published in 2023 at "Molecules"
DOI: 10.3390/molecules28020783
Abstract: The Bcl-2 protein has a vital function in controlling the programmed cell doom of mitochondria. If programmed cell death signals are obstructed, an imbalance between cell survival and death will occur, which is a significant… read more here.
Keywords: npatlas database; products atlas; natural products; atlas npatlas ... See more keywords
Design, Synthesis, Anticancer Activity, and Solid Lipid Nanoparticle Formulation of Indole- and Benzimidazole-Based Compounds as Pro-Apoptotic Agents Targeting Bcl-2 Protein
Sign Up to like & getrecommendations! Published in 2021 at "Pharmaceuticals"
DOI: 10.3390/ph14020113
Abstract: Cancer is a multifactorial disease necessitating identification of novel targets for its treatment. Inhibition of Bcl-2 for triggered pro-apoptotic signaling is considered a promising strategy for cancer treatment. Within the current work, we aimed to… read more here.
Keywords: bcl protein; pro apoptotic; cancer; lipid nanoparticle ... See more keywords