Photocrosslinking Approach to Investigate Protein Interactions in the BCL-2 Family.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-8861-7_9
Abstract: The Bcl-2 family of proteins regulates mitochondrial outer membrane permeability thereby making life or death decisions for cells. Most of Bcl-2 proteins contain hydrophobic regions that are embedded in intracellular membranes such as mitochondria. These… read more here.
Keywords: photocrosslinking approach; interactions bcl; bcl proteins; bcl family ... See more keywords
Noncanonical Cell Fate Regulation by Bcl-2 Proteins.
Sign Up to like & getrecommendations! Published in 2020 at "Trends in cell biology"
DOI: 10.1016/j.tcb.2020.03.004
Abstract: Bcl-2 proteins are widely known as key controllers of mitochondrial outer membrane permeabilization, arguably the most important step of intrinsic apoptosis. Accumulating evidence indicate that most, if not all, members of the Bcl-2 protein family… read more here.
Keywords: noncanonical cell; bcl proteins; cell; cell fate ... See more keywords
Expanding the Cancer Arsenal with Targeted Therapies: Disarmament of the Antiapoptotic Bcl-2 Proteins by Small Molecules.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.5b01888
Abstract: A hallmark of cancer is the evasion of apoptosis, which is often associated with the upregulation of the antiapoptotic members of the Bcl-2 family of proteins. The prosurvival function of the antiapoptotic Bcl-2 proteins is… read more here.
Keywords: bcl proteins; bcl family; antiapoptotic bcl; bcl ... See more keywords
What can we learn from mice lacking pro-survival BCL-2 proteins to advance BH3 mimetic drugs for cancer therapy?
Sign Up to like & getrecommendations! Published in 2022 at "Cell death and differentiation"
DOI: 10.1038/s41418-022-00987-0
Abstract: In many human cancers the control of apoptosis is dysregulated, for instance as a result of the overexpression of pro-survival BCL-2 proteins. This promotes tumorigenesis by protecting nascent neoplastic cells from stress and renders malignant… read more here.
Keywords: bh3 mimetic; survival bcl; bcl; bcl proteins ... See more keywords
Crystal structures of ORFV125 provide insight into orf virus-mediated inhibition of apoptosis
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical Journal"
DOI: 10.1042/bcj20200776
Abstract: Premature apoptosis of cells is a strategy utilized by multicellular organisms to counter microbial threats. Orf virus (ORFV) is a large double-stranded DNA virus belonging to the poxviridae. ORFV encodes for an apoptosis inhibitory protein… read more here.
Keywords: orf virus; apoptosis; virus; bcl ... See more keywords
How Do Hexokinases Inhibit Receptor-Mediated Apoptosis?
Sign Up to like & getrecommendations! Published in 2022 at "Biology"
DOI: 10.3390/biology11030412
Abstract: Simple Summary In multicellular animals, cells autonomously respond to lethal stress by inducing cell death programs. The most common regulated cell death is apoptosis. Cells protect their neighbors from damage by their cell contents or… read more here.
Keywords: bcl proteins; cell; receptor mediated; apoptosis ... See more keywords
Metazoans and Intrinsic Apoptosis: An Evolutionary Analysis of the Bcl-2 Family
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23073691
Abstract: The B-cell lymphoma-2 (Bcl-2) family is a group of genes regulating intrinsic apoptosis, a process controlling events such as development, homeostasis and the innate and adaptive immune responses in metazoans. In higher organisms, Bcl-2 proteins… read more here.
Keywords: bcl family; intrinsic apoptosis; bcl proteins; family ... See more keywords