Human BCL10 Deficiency due to Homozygosity for a Rare Allele
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Clinical Immunology"
DOI: 10.1007/s10875-020-00760-3
Abstract: In 2014, a child with broad combined immunodeficiency (CID) who was homozygous for a private BCL10 allele was reported to have complete inherited human BCL10 deficiency. In the present study, we report a new BCL10… read more here.
Keywords: rare allele; human bcl10; bcl10; bcl10 deficiency ... See more keywords
USP12 promotes CD4+ T cell responses through deubiquitinating and stabilizing BCL10
Sign Up to like & getrecommendations! Published in 2021 at "Cell Death and Differentiation"
DOI: 10.1038/s41418-021-00787-y
Abstract: Deubiquitinases (DUBs) regulate diverse biological processes and represent a novel class of drug targets. However, the biological function of only a small fraction of DUBs, especially in adaptive immune response regulation, is well-defined. In this… read more here.
Keywords: usp12 promotes; bcl10; promotes cd4; cd4 cell ... See more keywords
A nucleation barrier spring-loads the CBM signalosome for binary activation
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.1101/2022.01.28.477912
Abstract: Immune cells activate in a binary, switch-like fashion that involves proteins polymerizing into large complexes known as signalosomes. The switch-like nature of signalosome formation has been proposed to result from large energy barriers to polymer… read more here.
Keywords: bcl10; nucleation; barrier; cbm signalosome ... See more keywords
Assembly mechanism of the CARMA1-BCL10-MALT1-TRAF6 signalosome.
Sign Up to like & getrecommendations! Published in 2018 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.2210/pdb6bze/pdb
Abstract: The CARMA1-BCL10-MALT1 (CBM) signalosome is a central mediator of T cell receptor and B cell receptor-induced NF-κB signaling that regulates multiple lymphocyte functions. While caspase-recruitment domain (CARD) membrane-associated guanylate kinase (MAGUK) protein 1 (CARMA1) nucleates… read more here.
Keywords: malt1 traf6; bcl10; malt1; bcl10 malt1 ... See more keywords
By regulating miR-182-5p/BCL10/CYCS, sufentanil reduces the apoptosis of umbilical cord mesenchymal stem cells caused by ropivacaine.
Sign Up to like & getrecommendations! Published in 2019 at "Bioscience trends"
DOI: 10.5582/bst.2018.01291
Abstract: Sufentanil is a type of opioid analgesic and is usually used to facilitate painless labor in combination with the local anesthetic ropivacaine. One aim of the current study was to investigate the effects of sufentanil… read more here.
Keywords: umbilical cord; sufentanil; bcl10; ropivacaine ... See more keywords