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   Articles with "bcl11b" as a keyword



BCL11B‐Related Dystonia: Further Evidence of an Emerging Cause of Childhood‐Onset Generalized Dystonia

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recommendations! Published in 2024 at "Movement Disorders Clinical Practice"

DOI: 10.1002/mdc3.14084

Abstract: BCL11B encodes for a bifunctional protein which acts both as a transcriptional repressor and transactivator, involved in dermis, dentition, immune and nervous system development. 1 Heterozygous BCL11B mutations are associated with a neurodevelopmental syndrome featuring… read more here.

Keywords: dystonia evidence; bcl11b; bcl11b related; emerging cause ... See more keywords
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Gut commensals suppress interleukin-2 production through microRNA-200/BCL11B and microRNA-200/ETS-1 axes in lamina propria leukocytes of murine large intestine.

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recommendations! Published in 2020 at "Biochemical and biophysical research communications"

DOI: 10.1016/j.bbrc.2020.10.103

Abstract: The role of microRNAs (miRNAs) in how microbiota influence the host intestinal immune system is not fully understood. We compared the expression profiles of miRNAs and mRNAs in lamina propria leukocytes (LPL) in the large… read more here.

Keywords: production; microrna 200; spf mice; lamina propria ... See more keywords
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BCL11B-related disorder in two canadian children: Expanding the clinical phenotype.

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recommendations! Published in 2020 at "European journal of medical genetics"

DOI: 10.1016/j.ejmg.2020.104007

Abstract: The product of the BCL11B (B-Cell Leukemia 11) gene is a bi-functional transcriptional regulator that can act as either a repressor or an activator. It plays an important role in the development of the nervous,… read more here.

Keywords: related disorder; clinical phenotype; bcl11b; disorder ... See more keywords

BCL11B mutations in patients affected by a neurodevelopmental disorder with reduced type 2 innate lymphoid cells

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recommendations! Published in 2018 at "Brain"

DOI: 10.1093/brain/awy173

Abstract: The transcription factor BCL11B is essential for development of the nervous and the immune system, and Bcl11b deficiency results in structural brain defects, reduced learning capacity, and impaired immune cell development in mice. However, the… read more here.

Keywords: bcl11b; type innate; innate lymphoid; lymphoid cells ... See more keywords

Optimizing Bcl11b timing enhances natural killer cell differentiation and cytotoxicity from human pluripotent stem cells for effective immunotherapy

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recommendations! Published in 2025 at "Blood"

DOI: 10.1182/blood-2025-3153

Abstract: Human hematopoietic stem cells (HSCs) derived from induced pluripotent stem cells (iPSCs) are revolutionizing regenerative medicine by providing hope for therapies, disease modeling, and drug discovery in hematological disorders and beyond. However, producing functional iPSC-derived… read more here.

Keywords: stem cells; cell; bcl11b; pluripotent stem ... See more keywords

Venetoclax plus gilteritinib is effective in preclinical models of FLT3-mutant BCL11B-a lineage-ambiguous leukemia.

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recommendations! Published in 2025 at "Blood"

DOI: 10.1182/blood.2025028985

Abstract: Aberrant activation of BCL11B ("BCL11B-a") defines a subtype of lineage ambiguous leukemias with T-lymphoid and myeloid features, co-occurring activating FLT3 mutations, and a stem/progenitor immunophenotype and gene expression profile. As with other lineage ambiguous leukemias,… read more here.

Keywords: lineage ambiguous; preclinical models; bcl11b; venetoclax plus ... See more keywords

Bcl11b—A Critical Neurodevelopmental Transcription Factor—Roles in Health and Disease

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recommendations! Published in 2017 at "Frontiers in Cellular Neuroscience"

DOI: 10.3389/fncel.2017.00089

Abstract: B cell leukemia 11b (Bcl11b) is a zinc finger protein transcription factor with a multiplicity of functions. It works as both a genetic suppressor and activator, acting directly, attaching to promoter regions, as well as… read more here.

Keywords: transcription factor; bcl11b; health disease; disease ... See more keywords

Function of B-Cell CLL/Lymphoma 11B in Glial Progenitor Proliferation and Oligodendrocyte Maturation

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recommendations! Published in 2018 at "Frontiers in Molecular Neuroscience"

DOI: 10.3389/fnmol.2018.00004

Abstract: B-cell CLL/lymphoma 11B (Bcl11b) – a C2H2 zinc finger transcriptional factor – is known to regulate neuronal differentiation and function in the development of the central nervous system (CNS). Although its expression is reduced during… read more here.

Keywords: bcl11b; cll lymphoma; expression; lymphoma 11b ... See more keywords

Generation of Inducible BCL11B Knockout in TAL1/LMO1 Transgenic Mouse T Cell Leukemia/Lymphoma Model

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recommendations! Published in 2022 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms23094932

Abstract: The B-cell CLL/lymphoma 11B gene (BCL11B) plays a crucial role in T-cell development, but its role in T-cell malignancies is still unclear. To study its role in the development of T-cell neoplasms, we generated an… read more here.

Keywords: inducible bcl11b; cell; leukemia lymphoma; bcl11b ... See more keywords