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   Articles with "bcl2" as a keyword



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Codelivery of BCL2 and MCL1 Inhibitors Enabled by Phenylboronic Acid‐Functionalized Polypeptide Nanovehicles for Synergetic and Potent Therapy of Acute Myeloid Leukemia

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recommendations! Published in 2023 at "Advanced Science"

DOI: 10.1002/advs.202204866

Abstract: Acute myeloid leukemia (AML) is the most refractory hematologic malignancy characterized by acute onset, rapid progression, and high recurrence rate. Here, codelivery of BCL2 (ABT199) and MCL1 (TW37) inhibitors using phenylboronic acid‐functionalized polypeptide nanovehicles to… read more here.

Keywords: bcl2; mcl1; phenylboronic acid; acid functionalized ... See more keywords
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Cimetidine a promising radio‐protective agent through modulating Bax/Bcl2 ratio: An in vivo study in male rats

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recommendations! Published in 2020 at "Journal of Cellular Physiology"

DOI: 10.1002/jcp.29692

Abstract: Radiotherapy is one of the most effective modalities for treatment of neoplastic diseases. Radiation damage is to a large extent caused by overproduction of reactive oxygen species. To improve the therapeutic index, identifying effective substances… read more here.

Keywords: bax; bax bcl2; bcl2 ratio; study ... See more keywords
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Tanshinone I restrains osteosarcoma progression by regulating circ_0000376/miR-432-5p/BCL2 axis.

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recommendations! Published in 2021 at "Molecular and cellular biochemistry"

DOI: 10.1007/s11010-021-04257-4

Abstract: Circular RNAs (circRNAs) have been identified as important regulators in cancer progression. Nevertheless, little is known about the biological function of circ_0000376 in the progression of osteosarcoma (OS). Cell viability, colony formation ability, apoptosis, and… read more here.

Keywords: 0000376 mir; bcl2; mir 432; progression ... See more keywords
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Identification and functional comparison of Bcl2 splicing isoforms in mouse embryonic stem cells.

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recommendations! Published in 2020 at "Biochemical and biophysical research communications"

DOI: 10.1016/j.bbrc.2020.01.140

Abstract: Embryonic stem cells (ESCs) provide an ideal model for investigating developmental processes and are great sources for developing regenerative medicine. Harnessing apoptosis facilitates accurate recapitulation of signalling events during embryogenesis and allows efficient expansion of… read more here.

Keywords: medicine; stem cells; splicing isoforms; bcl2 ... See more keywords
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Novel BCL2 inhibitor, Disarib induces apoptosis by disruption of BCL2‐BAK interaction

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recommendations! Published in 2017 at "Biochemical Pharmacology"

DOI: 10.1016/j.bcp.2017.02.015

Abstract: ABSTRACT Apoptosis is a highly regulated pathway of programmed cell death relying on the fine balance between pro and antiapoptotic binding partners. Overexpression of the antiapoptotic protein BCL2 in several cancers makes it an ideal… read more here.

Keywords: bak interaction; bcl2 bak; disarib; bcl2 ... See more keywords
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BCL2 induced by LAMTOR3/MAPK is a druggable target of chemoradioresistance in mesenchymal lung cancer.

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recommendations! Published in 2017 at "Cancer letters"

DOI: 10.1016/j.canlet.2017.05.019

Abstract: Mesenchymal-type cancers after epithelial mesenchymal transition (EMT) were recently shown to acquire chemoresistance through expressing EMT specific transcription factors. However, druggable (or actionable) target(s) for chemoresistance in mesenchymal-type lung cancers remain unidentified. Here, we used… read more here.

Keywords: target; mesenchymal lung; bcl2; lung cancer ... See more keywords
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Epigenetic silencing of miRNA-143 regulates apoptosis by targeting BCL2 in human intervertebral disc degeneration.

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recommendations! Published in 2017 at "Gene"

DOI: 10.1016/j.gene.2017.07.043

Abstract: Accumulating evidence indicates that microRNAs can regulate the apoptosis of various cells. Apoptosis of nucleus pulposus cells plays an important role in the progression of intervertebral disc degeneration. The aim of this study is to… read more here.

Keywords: disc; intervertebral disc; mirna 143; bcl2 ... See more keywords
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Decreased BIM expression in BCL2-negative follicular lymphoma: a potential mechanism for resistance to apoptosis.

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recommendations! Published in 2020 at "Human pathology"

DOI: 10.1016/j.humpath.2020.09.016

Abstract: Follicular lymphoma (FL) is characterized by the t(14;18)(q32;q21), leading to overexpression of the anti-apoptotic molecule BCL2; however, a subset of FLs lack BCL2 rearrangement and BCL2 expression by IHC. In this study we evaluated expression… read more here.

Keywords: bcl2 fls; ihc; follicular lymphoma; expression ... See more keywords

Importance of Hypericin-Bcl2 interactions for biological effects at subcellular levels.

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recommendations! Published in 2019 at "Photodiagnosis and photodynamic therapy"

DOI: 10.1016/j.pdpdt.2019.08.016

Abstract: Hypericin (Hyp) is a naturally occurring compound used as photosensitizer in photodynamic therapy and diagnosis. Recently, we have shown that Hyp presence alone, without illumination, resulted in substantial biological effects at several sub-cellular levels. Hyp… read more here.

Keywords: hyp; bh3; hypericin; bcl2 ... See more keywords
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The relationship between p53, Bcl2 proteins and histological grade in colorectal adenocarcinoma associated with type 2 diabetes and obesity

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recommendations! Published in 2020 at "Proceedings of the Nutrition Society"

DOI: 10.1017/s0029665120005753

Abstract: Abstract Introduction The aim of our study was to evaluate the expression of p53 protein in colorectal adenocarcinoma in diabetic (type 2) obese vs non-obese vs and to analyse p53, Bcl2 proteins expression in type… read more here.

Keywords: diabetic patients; colorectal adenocarcinoma; grade; bcl2 ... See more keywords
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BCL2 super-expressor diffuse large B-cell lymphoma: a distinct subgroup associated with poor prognosis

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recommendations! Published in 2021 at "Modern Pathology"

DOI: 10.1038/s41379-021-00962-z

Abstract: Overexpression of the BCL2 protein has been reported as a poor prognostic factor for diffuse large B-cell lymphoma (DLBCL). However, there are currently no standardized criteria for evaluating BCL2 protein expression. We aimed to evaluate… read more here.

Keywords: super expressor; bcl2 super; cell; bcl2 ... See more keywords