Abstract 6155: Lurbinectedin exhibits combinatorial activity with BCL2/BCL2L1 inhibitors in vitro and in vivo by modulation of MCL1 expression
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-6155
Abstract: Lurbinectedin (Zepzelca) is a marine-derived anti-tumor agent currently approved for metastatic small cell lung cancer (SCLC). Lurbinectedin has been previously shown to exert its anti-tumor effect by binding to the minor groove of DNA and… read more here.
Keywords: mcl1; tumor; bcl2 bcl2l1; lurbinectedin ... See more keywords
Variable BCL2/BCL2L1 ratio in multiple myeloma with t(11;14).
Sign Up to like & getrecommendations! Published in 2018 at "Blood"
DOI: 10.1182/blood-2018-09-876433
Abstract: To the editor: Multiple myeloma (MM) is characterized by a large diversity of genetic abnormalities.[1][1][⇓][2]-[3][3] They can be classified in 3 categories: copy number changes, mutations, and translocations involving mainly the IGH gene at 14q32.… read more here.
Keywords: myeloma; variable bcl2; multiple myeloma; ratio multiple ... See more keywords
Overexpression of Bcl2 and Bcl2L1 Can Suppress Betanodavirus-Induced Type III Cell Death and Autophagy Induction in GF-1 Cells
Sign Up to like & getrecommendations! Published in 2022 at "Symmetry"
DOI: 10.3390/sym14020360
Abstract: Betanodavirus infection induces viral nervous necrosis (VNN) in fish. However, the role of cell death and autophagy in the pathogenesis of VNN remains unknown. This study aimed to investigate the effect of red-spotted grouper nervous… read more here.
Keywords: cell death; death autophagy; bcl2 bcl2l1; autophagy ... See more keywords