High grade B-cell lymphoma with rearrangements of MYC and BCL2 and/or BCL6: Double hit and triple hit lymphomas and double expressing lymphoma.
Sign Up to like & getrecommendations! Published in 2017 at "Blood reviews"
DOI: 10.1016/j.blre.2016.09.004
Abstract: Diffuse large B-cell lymphomas with aberrations in MYC, BCL2 and/or BCL6 by genetic alterations or protein expression represent a group of high grade B-cell lymphomas with inferior outcomes when treated with standard RCHOP chemotherapy. As… read more here.
Keywords: lymphoma; bcl2 bcl6; high grade; myc bcl2 ... See more keywords
Analyse par hybridation in situ en fluorescence (FISH) d’une série de 47 lymphomes avec le système BioView®
Sign Up to like & getrecommendations! Published in 2017 at "Morphologie"
DOI: 10.1016/j.morpho.2017.07.012
Abstract: Objet Les systemes de capture et d’analyse d’image permettent une analyse par FISH semi-automatisee des coupes de tissus fixes par le formol et inclus en paraffine. Le service de cytogenetique et biologie cellulaire du CHU… read more here.
Keywords: bcl2 bcl6; par hybridation; analyse par; bioview ... See more keywords
Somatic copy number gains in MYC, BCL2, and BCL6 identifies a subset of aggressive alternative-DH/TH DLBCL patients
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DOI: 10.1038/s41408-020-00382-3
Abstract: Double/triple hit lymphoma (DH/TH), known as high-grade B-cell lymphoma (HGBL), is an aggressive diffuse large B cell lymphoma (DLBCL), defined as having concurrent MYC, BCL2, and/or BCL6 gene rearrangements. While gene rearrangements represent significant genetic… read more here.
Keywords: bcl2 bcl6; copy number; dlbcl; myc bcl2 ... See more keywords
Extra copies of MYC, BCL2, and BCL6 and outcome in patients with diffuse large B-cell lymphoma.
Sign Up to like & getrecommendations! Published in 2020 at "Blood advances"
DOI: 10.1182/bloodadvances.2020001551
Abstract: High-grade B-cell lymphoma (HGBL) with translocations involving MYC and BCL2 or BCL6 comprises ∼10% of cases of diffuse large B-cell lymphoma (DLBCL) and carries a poor prognosis. The incidence, prognosis, and optimal therapy for DLBCL… read more here.
Keywords: bcl2 bcl6; myc bcl2; copies myc; extra copies ... See more keywords
Overexpression of BCL2, BCL6, VEGFR1 and TWIST1 in Circulating Tumor Cells Derived from Patients with DLBCL Decreases Event-Free Survival
Sign Up to like & getrecommendations! Published in 2022 at "OncoTargets and Therapy"
DOI: 10.2147/ott.s386562
Abstract: Purpose Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous malignant lymphoid neoplasm and is the most common subtype of non-Hodgkin lymphoma in adults. More than half of patients with DLBCL can achieve remission with standard… read more here.
Keywords: overexpression; bcl2 bcl6; bcl6 vegfr1; patients dlbcl ... See more keywords
Inferior survival in high-grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements is not associated with MYC/IG gene rearrangements
Sign Up to like & getrecommendations! Published in 2018 at "Haematologica"
DOI: 10.3324/haematol.2018.190157
Abstract: High-grade B-cell lymphomas with MYC and BCL2 and/or BCL6 rearrangements (double-/triple-hit lymphoma) have an aggressive clinical course. We investigated the prognostic value of transformation from low-grade lymphoma, cytological features (high grade versus large cell), MYC… read more here.
Keywords: bcl2 bcl6; high grade; grade; myc bcl2 ... See more keywords
High-grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements: Biopsy analysis of 70 cases from the Slovak Lymphoma Registry.
Sign Up to like & getrecommendations! Published in 2022 at "Neoplasma"
DOI: 10.4149/neo_2022_220318n300
Abstract: We performed a twelve-year retrospective analysis of diffuse large B-cell lymphoma (DLBCL) patients' biopsies with rearrangements of genes MYC, BCL2, and/or BCL6, commonly referred to as double-hit and triple-hit high-grade B-cell lymphomas (DH/TH HGBL). Our… read more here.
Keywords: myc bcl2; cell; bcl6; analysis ... See more keywords