Expression Ratios of the Antiapoptotic BCL2 Family Members Dictate the Selective Addiction of Kaposi’s Sarcoma-Associated Herpesvirus-Transformed Primary Effusion Lymphoma Cell Lines to MCL1
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Virology"
DOI: 10.1128/jvi.01360-22
Abstract: Primary effusion lymphoma (PEL) is caused by Kaposi’s sarcoma-associated herpesvirus. We showed previously that PEL cell lines require the antiapoptotic protein MCL1 for survival but not the other BCL2 family proteins. ABSTRACT Kaposi’s sarcoma-associated herpesvirus… read more here.
Keywords: bcl2 family; mcl1; family; primary effusion ... See more keywords
Combinatorial BCL2 Family Expression in Acute Myeloid Leukemia Stem Cells Predicts Clinical Response to Azacitidine/Venetoclax
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Discovery"
DOI: 10.1158/2159-8290.cd-22-0939
Abstract: Combinatorial levels of BCL2 family members in acute myeloid leukemia stem cells are a key denominator of response to BCL2 inhibitor therapy, and flow cytometry–based measurements predict response in patients both reliably and quickly. read more here.
Keywords: myeloid leukemia; bcl2 family; leukemia stem; acute myeloid ... See more keywords