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Published in 2017 at "Blood"
DOI: 10.1182/blood-2016-02-699363
Abstract: The bone marrow (BM) provides a protective microenvironment to support the survival of leukemic cells and influence their response to therapeutic agents. In acute myeloid leukemia (AML), the high rate of relapse may in part…
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Keywords:
bcl2 inhibitors;
cell;
bcl2;
bone marrow ... See more keywords
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Published in 2021 at "Blood"
DOI: 10.1182/blood.2020006785
Abstract: BCL2 and MCL1 are commonly expressed pro-survival (anti-apoptotic) proteins in hematological cancers and play important roles in their biology either through dysregulation or by virtue of intrinsic importance to the cell-of-origin of the malignancy. A…
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Keywords:
bcl2 inhibitors;
mcl1 inhibitors;
bh3 mimetics;
inhibitors mcl1 ... See more keywords