Bcl6 modulates innate immunity by controlling macrophage activity and plays critical role in experimental autoimmune encephalomyelitis
Sign Up to like & getrecommendations! Published in 2020 at "European Journal of Immunology"
DOI: 10.1002/eji.201948299
Abstract: The B‐cell CLL/lymphoma 6 (Bcl6) oncogenic repressor is a master regulator of humoral immunity and B‐cell lymphomagenesis. Although much research has focused on its regulation and function of GC B cells and T cells, the… read more here.
Keywords: innate immunity; bcl6; role; macrophage activity ... See more keywords
Chemically Induced Degradation of the Oncogenic Transcription Factor BCL6.
Sign Up to like & getrecommendations! Published in 2017 at "Cell reports"
DOI: 10.1016/j.celrep.2017.08.081
Abstract: The transcription factor BCL6 is a known driver of oncogenesis in lymphoid malignancies, including diffuse large B cell lymphoma (DLBCL). Disruption of its interaction with transcriptional repressors interferes with the oncogenic effects of BCL6. We… read more here.
Keywords: transcription factor; degradation; bcl6; factor bcl6 ... See more keywords
Discovery of an Irreversible and Cell-Active BCL6 Inhibitor Selectively Targeting Cys53 Located at the Protein-Protein Interaction Interface.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemistry"
DOI: 10.1021/acs.biochem.7b00732
Abstract: B-cell lymphoma 6 (BCL6) is the most frequently involved oncogene in diffuse large B-cell lymphomas (DLBCLs). BCL6 shows potent transcriptional repressor activity through interactions with its corepressors, such as BCL6 corepressor (BCOR). The inhibition of… read more here.
Keywords: protein; inhibitor; inhibition; bcl6 ... See more keywords
Improved Binding Affinity and Pharmacokinetics Enable Sustained Degradation of BCL6 In Vivo
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medicinal Chemistry"
DOI: 10.1021/acs.jmedchem.1c02175
Abstract: The transcriptional repressor BCL6 is an oncogenic driver found to be deregulated in lymphoid malignancies. Herein, we report the optimization of our previously reported benzimidazolone molecular glue-type degrader CCT369260 to CCT373566, a highly potent probe… read more here.
Keywords: bcl6 vivo; vivo; improved binding; bcl6 ... See more keywords
Development of a Novel B-Cell Lymphoma 6 (BCL6) PROTAC To Provide Insight into Small Molecule Targeting of BCL6.
Sign Up to like & getrecommendations! Published in 2018 at "ACS chemical biology"
DOI: 10.1021/acschembio.8b00698
Abstract: B-cell lymphoma 6 (BCL6) inhibition is a promising mechanism for treating hematological cancers but high quality chemical probes are necessary to evaluate its therapeutic potential. Here we report potent BCL6 inhibitors that demonstrate cellular target… read more here.
Keywords: bcl6 protac; lymphoma bcl6; bcl6; cell ... See more keywords
Interferon γ is a STAT1-dependent direct inducer of BCL6 expression in imatinib-treated chronic myeloid leukemia cells
Sign Up to like & getrecommendations! Published in 2017 at "Oncogene"
DOI: 10.1038/onc.2017.85
Abstract: B-cell CLL/lymphoma 6 (BCL6) exerts oncogenic effects in several human hematopoietic malignancies including chronic myeloid leukemia (CML), where BCL6 expression was shown to be essential for CML stem cell survival and self-renewal during imatinib mesylate… read more here.
Keywords: cml stem; cml; ifn; bcl6 ... See more keywords
Association of increased eomesodermin, BCL6, and granzyme B expression with major clinical manifestations of Hashimoto’s thyroiditis – an observational study
Sign Up to like & getrecommendations! Published in 2018 at "Immunological Investigations"
DOI: 10.1080/08820139.2018.1423571
Abstract: ABSTRACT Purpose Studies of cytotoxic T cells and their respective lineage master regulators have been limited in Hashimoto’s thyroiditis (HT). It is unclear whether their transcriptomes are changed in HT patients and how these changes… read more here.
Keywords: hashimoto thyroiditis; disease; bcl6; clinical manifestations ... See more keywords
Quadruple‐hit pleomorphic mantle cell lymphoma with MYC, BCL2, BCL6, and CCND1 gene rearrangements
Sign Up to like & getrecommendations! Published in 2021 at "British Journal of Haematology"
DOI: 10.1111/bjh.17729
Abstract: B-cell lymphomas that concurrently carry MYC, BCL2 and/ or BCL6 gene rearrangements – so-called double-hit or triple-hit lymphomas – are rare entities associated with poor prognosis. B-cell lymphomas with translocations involving MYC, BCL2, BCL6 and… read more here.
Keywords: bcl6; ccnd1; bcl2; gene ... See more keywords
B-cell Lymphoma 6 (BCL6): From Master Regulator of Humoral Immunity to Oncogenic Driver in Pediatric Cancers
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Cancer Research"
DOI: 10.1158/1541-7786.mcr-22-0567
Abstract: Abstract B-cell lymphoma 6 (BCL6) is a protooncogene in adult and pediatric cancers, first identified in diffuse large B-cell lymphoma (DLBCL) where it acts as a repressor of the tumor suppressor TP53, conferring survival, protection,… read more here.
Keywords: pediatric cancers; cell lymphoma; humoral immunity; lymphoma bcl6 ... See more keywords
BI-3802 Promotes Polymerization and Degradation of Oncogenic BCL6.
Sign Up to like & getrecommendations! Published in 2020 at "Cancer discovery"
DOI: 10.1158/2159-8290.cd-rw2020-173
Abstract: The small-molecule drug BI-3802 induced the formation of BCL6 filaments leading to degradation. read more here.
Keywords: 3802 promotes; degradation oncogenic; degradation; promotes polymerization ... See more keywords
Correlation between B-cell lymphoma 6 with the balance of T helper-1/2 and severity of allergic rhinitis.
Sign Up to like & getrecommendations! Published in 2023 at "Allergologia et immunopathologia"
DOI: 10.15586/aei.v51i1.673
Abstract: OBJECTIVE Allergic rhinitis (AR) is a prevailing immune disorder affecting the nasal mucosa. B-cell lymphoma 6 (BCL6) imposes essential roles in immunity. This study probed into the serum expression of BCL6 and its effect on… read more here.
Keywords: cell; expression; bcl6; bcl6 expression ... See more keywords