Discovery of Pyrazolo[1,5-a]pyrimidine B-Cell Lymphoma 6 (BCL6) Binders and Optimization to High Affinity Macrocyclic Inhibitors.
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DOI: 10.1021/acs.jmedchem.7b00359
Abstract: Inhibition of the protein-protein interaction between B-cell lymphoma 6 (BCL6) and corepressors has been implicated as a therapeutic target in diffuse large B-cell lymphoma (DLBCL) cancers and profiling of potent and selective BCL6 inhibitors are… read more here.
Keywords: lymphoma bcl6; pyrazolo pyrimidine; bcl6 binders; cell ... See more keywords