Dysregulated BCL9 Controls Tumorigenicity and Ferroptosis Susceptibility by Binding With Nrf2 in Thyroid Carcinoma
Sign Up to like & getrecommendations! Published in 2024 at "Molecular Carcinogenesis"
DOI: 10.1002/mc.23816
Abstract: Thyroid carcinoma (TC) is the most common malignant tumor of the endocrine system with increasing incidence. In this study, we found that BCL9 is markedly upregulated in human TC tumors and its expression is positively… read more here.
Keywords: ferroptosis; thyroid carcinoma; bcl9; bcl9 controls ... See more keywords
Wnt status-dependent oncogenic role of BCL9 and BCL9L in hepatocellular carcinoma
Sign Up to like & getrecommendations! Published in 2019 at "Hepatology International"
DOI: 10.1007/s12072-019-09977-w
Abstract: Background Activation of Wnt/β-catenin pathway is a frequent event in hepatocellular carcinoma and is associated with enhanced cell survival and proliferation. Therefore, targeting this signaling pathway is discussed as an attractive therapeutic approach for HCC… read more here.
Keywords: hepatocellular carcinoma; bcl9 bcl9l; hcc; wnt ... See more keywords
BCL9/BCL9L in hepatocellular carcinoma: Will it or Wnt it be the next therapeutic target?
Sign Up to like & getrecommendations! Published in 2020 at "Hepatology international"
DOI: 10.1007/s12072-020-10059-5
Abstract: In the past few decades, hepatocellular carcinoma (HCC) has emerged as the most rapidly rising cause of cancer-related mortality in the USA [1]. Even though we are gradually getting a grip on the traditional risk… read more here.
Keywords: hepatocellular carcinoma; bcl9 bcl9l; hcc; wnt ... See more keywords
Endometrial epithelial cells-derived exosomes deliver microRNA-30c to block the BCL9/Wnt/CD44 signaling and inhibit cell invasion and migration in ovarian endometriosis
Sign Up to like & getrecommendations! Published in 2022 at "Cell Death Discovery"
DOI: 10.1038/s41420-022-00941-6
Abstract: Endometriosis (EMs) is a benign gynecological disorder showing some tumor-like migratory and invasive phenotypes. This study intended to investigate the role of microRNA-30c (miR-30c) in EMs, which is involved with B-cell lymphoma 9 (BCL9), an… read more here.
Keywords: bcl9; mir 30c; ecto eecs; wnt cd44 ... See more keywords
Hypoxia activates Wnt/β-catenin signaling by regulating the expression of BCL9 in human hepatocellular carcinoma
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/srep40446
Abstract: The Wnt/β-catenin signaling is abnormally activated in the progression of hepatocellular carcinoma (HCC). BCL9 is an essential co-activator in the Wnt/β-catenin signaling. Importantly, BCL9 is absent from tumors originating from normal cellular counterparts and overexpressed… read more here.
Keywords: hcc; catenin signaling; bcl9; hypoxia ... See more keywords
Abstract 3275: Reprogramming of MDSCs by ST316, a clinical peptide antagonist of b-Catenin/BCL9, enhances anti-tumor immuno- and chemotherapy
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Research"
DOI: 10.1158/1538-7445.am2025-3275
Abstract: Myeloid-derived suppressor cells (MDSCs) are a diverse group of immune cells that play critical roles in mediating immune-suppression. They are often associated with poor responses in various cancer types and represent an attractive target for… read more here.
Keywords: mdscs; catenin; peptide antagonist; tumor ... See more keywords
LncRNA MNX1-AS1 Contributes to Laryngeal Squamous Cell Carcinoma Growth and Migration by Regulating mir-744-5p/bcl9/β-Catenin Axis
Sign Up to like & getrecommendations! Published in 2021 at "Cell Transplantation"
DOI: 10.1177/09636897211005682
Abstract: Increasing evidence has indicated that long noncoding RNAs (lncRNAs) are involved in the progression of laryngeal squamous cell carcinoma (LSCC). Here, we aimed to disclose the role of MNX1-AS1 in LSCC progression, and explore whether… read more here.
Keywords: cell; mnx1 as1; bcl9; mir 744 ... See more keywords
Inhibition of BCL9 Modulates the Cellular Landscape of Tumor-Associated Macrophages in the Tumor Immune Microenvironment of Colorectal Cancer
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2021.713331
Abstract: Tumor-associated macrophages (TAMs) are an indispensable part of the tumor microenvironment (TME), and they likely play a negative rather than positive role in cancer treatment. However, the cellular landscape and transcriptional profile regulation of TAMs… read more here.
Keywords: cellular landscape; tumor associated; bcl9; cancer ... See more keywords