Superfast Tetrazole-BCN Cycloaddition Reaction for Bioorthogonal Protein Labeling on Live Cells.
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DOI: 10.1021/jacs.1c10354
Abstract: Here we report the design of a superfast bioorthogonal ligation reactant pair comprising a sterically shielded, sulfonated tetrazole and bicyclo[6.1.0]non-4-yn-9-ylmethanol (BCN). The design involves placing a pair of water-soluble N-sulfonylpyrrole substituents at the C-phenyl ring… read more here.
Keywords: cycloaddition; bcn cycloaddition; bcn; cycloaddition reaction ... See more keywords