Optimization of peripheral blood volume for in silico reconstitution of the human B‐cell receptor repertoire
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DOI: 10.1002/2211-5463.13467
Abstract: B cells recognize antigens via membrane‐expressed B‐cell receptors (BCR) and antibodies. Similar human BCR sequences are frequently found at a significantly higher frequency than that theoretically calculated. Patients infected with SARS‐CoV2 and HIV or with… read more here.
Keywords: frequency; silico reconstitution; repertoire; bcr ... See more keywords
Asciminib vs bosutinib in CML patients pretreated with ≥2 tyrosine kinase inhibitors: Results from the Japanese subgroup analysis of ASCEMBL study
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DOI: 10.1002/cam4.5212
Abstract: Asciminib, a first‐in‐class, allosteric inhibitor of BCR‐ABL1 that acts by STAMP (Specifically Targeting the ABL Myristoyl Pocket), is a novel therapeutic option for patients with chronic myeloid leukemia (CML). In the global, phase 3, open‐label… read more here.
Keywords: ascembl study; cml; subgroup analysis; study ... See more keywords
BCR/ABL1–like acute lymphoblastic leukemia: How to diagnose and treat?
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DOI: 10.1002/cncr.31848
Abstract: BCR/ABL1–like acute lymphoblastic leukemia (ALL) accounts for 15% to 30% of B‐lineage ALL, with a peak of incidence occurring in adolescence. This subgroup of patients is characterized by a peculiar transcriptional profile that resembles that… read more here.
Keywords: bcr; abl1 like; lymphoblastic leukemia; acute lymphoblastic ... See more keywords
Improving naive B cell isolation by absence of CD45RB glycosylation and CD27 expression in combination with BCR isotype
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DOI: 10.1002/eji.202250013
Abstract: In past years ex vivo and in vivo experimental approaches involving human naive B cells have proven fundamental for elucidation of mechanisms promoting B cell differentiation in both health and disease. For such studies, it… read more here.
Keywords: cell; naive cell; cell isolation; naive cells ... See more keywords
Role and timing of new drugs in CLL
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DOI: 10.1002/hon.2397
Abstract: Signaling through the B‐cell receptor (BCR) has emerged as a potential key mechanism in CLL pathogenesis. It has been suggested that the BCR may induce antigen‐independent cell‐autonomous signaling in CLL. The importance of BCR signaling… read more here.
Keywords: role timing; timing new; cll; bcr ... See more keywords
Imaging the Interactions Between B Cells and Antigen-Presenting Cells.
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DOI: 10.1007/978-1-4939-7474-0_10
Abstract: In vivo, B cells are often activated by antigens that are displayed on the surface of antigen-presenting cells (APCs). Binding of membrane-associated antigens to the B cell receptor (BCR) causes rapid cytoskeleton-dependent changes in the… read more here.
Keywords: imaging interactions; bcr; presenting cells; model antigens ... See more keywords
Synthesis and biological evaluation of phenyl-amino-pyrimidine and indole/oxindole conjugates as potential BCR-ABL inhibitors
Sign Up to like & getrecommendations! Published in 2019 at "Medicinal Chemistry Research"
DOI: 10.1007/s00044-019-02318-4
Abstract: AbstractIndole/isatin conjugated phenyl-amino-pyrimidine derivatives have been synthesized, characterized and evaluated in vitro for their potential as BCR-ABL inhibitors. Among the series, all derivatives (7a–7o) were found to be more cytotoxic than standard Imatinib against K-562… read more here.
Keywords: bcr; abl inhibitors; amino pyrimidine; bcr abl ... See more keywords
Analysis of major BCR-ABL1 mRNA by digital polymerase chain reaction is useful for prediction of international scale
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Clinical Oncology"
DOI: 10.1007/s10147-019-01419-9
Abstract: BackgroundMajor BCR-ABL1 mRNA in patients with chronic myeloid leukemia (CML) has generally been analysed by real-time polymerase chain reaction (PCR). Application of the international scale (IS) for the quantification of major BCR-ABL1 mRNA has been… read more here.
Keywords: bcr; real time; pcr; abl1 mrna ... See more keywords
Small-volume lymph node involvement and biochemical recurrence after robot-assisted radical prostatectomy with extended lymph node dissection in prostate cancer
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DOI: 10.1007/s10147-020-01682-1
Abstract: Background We investigated prognostic factors for biochemical recurrence (BCR) after robot-assisted radical prostatectomy (RARP) with extended pelvic lymph node (LN) dissection. Methods We included 173 patients who underwent RARP with extended pelvic LN dissection without… read more here.
Keywords: bcr; risk; positive lns; dissection ... See more keywords
The Hidden Pathogenesis of CML: Is BCR-ABL1 the First Event?
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DOI: 10.1007/s11899-019-00549-1
Abstract: Identification of the BCR-ABL1 fusion oncogene in patients diagnosed with chronic myeloid leukemia (CML) led to the development of targeted therapy responsible for the dramatic survival benefits observed in the past two decades. However, despite… read more here.
Keywords: bcr; cml; hidden pathogenesis; event ... See more keywords
Growth of B Cell Receptor Microclusters Is Regulated by PIP2 and PIP3 Equilibrium and Dock2 Recruitment and Activation.
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DOI: 10.1016/j.celrep.2017.10.117
Abstract: The growth of B cell receptor (BCR) microclusters upon antigen stimulation drives B cell activation. Here, we show that PI3K-mediated PIP3 production is required for the growth of BCR microclusters. This growth is likely inhibited… read more here.
Keywords: bcr; dock2; cell receptor; growth cell ... See more keywords