Optimization of peripheral blood volume for in silico reconstitution of the human B‐cell receptor repertoire
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DOI: 10.1002/2211-5463.13467
Abstract: B cells recognize antigens via membrane‐expressed B‐cell receptors (BCR) and antibodies. Similar human BCR sequences are frequently found at a significantly higher frequency than that theoretically calculated. Patients infected with SARS‐CoV2 and HIV or with… read more here.
Keywords: frequency; silico reconstitution; repertoire; bcr ... See more keywords
A somatic hypermutation–based machine learning model stratifies individuals with Crohn's disease and controls
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DOI: 10.1101/gr.276683.122
Abstract: Crohn's disease (CD) is a chronic relapsing–remitting inflammatory disorder of the gastrointestinal tract that is characterized by altered innate and adaptive immune function. Although massively parallel sequencing studies of the T cell receptor repertoire identified… read more here.
Keywords: disease; machine learning; somatic hypermutation; crohn disease ... See more keywords
Antibody repertoire sequencing analysis
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DOI: 10.3724/abbs.2022062
Abstract: High-throughput sequencing for B cell receptor (BCR) repertoire provides useful insights for the adaptive immune system. With the continuous development of the BCR-seq technology, many efforts have been made to develop methods for analyzing the… read more here.
Keywords: antibody repertoire; bcr repertoire; analysis; repertoire ... See more keywords