Bromodomain Interactions with Acetylated Histone 4 Peptides in the BRD4 Tandem Domain: Effects on Domain Dynamics and Internal Flexibility
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DOI: 10.1021/acs.biochem.2c00226
Abstract: The bromodomain and extra-terminal (BET) protein BRD4 regulates gene expression via recruitment of transcriptional regulatory complexes to acetylated chromatin. Like other BET proteins, BRD4 contains two bromodomains, BD1 and BD2, that can interact cooperatively with… read more here.
Keywords: histone; bd1 bd2; bromodomain; order parameters ... See more keywords
Selective targeting of BD1 and BD2 of the BET proteins in cancer and immunoinflammation
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DOI: 10.1126/science.aaz8455
Abstract: Bromodomain inhibitors revisited Bromodomain and extraterminal domain (BET) proteins contribute to the pathogenesis of cancer and immune diseases through their effects on transcriptional regulation. BET proteins contain two nearly identical bromodomains, BD1 and BD2, structural… read more here.
Keywords: bd1 bd2; bet; cancer; bet proteins ... See more keywords