An immunomodulatory antibody-drug conjugate (ADC) targeting BDCA2 strongly suppresses pDC function and glucocorticoid responsive genes.
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DOI: 10.1093/rheumatology/kead219
Abstract: OBJECTIVES Blood dendritic cell antigen 2 (BDCA2) is exclusively expressed on plasmacytoid dendritic cells (pDCs) whose uncontrolled production of type I interferon (IFN-I) is crucial in pathogenesis of systemic lupus erythematosus (SLE) and other autoimmune… read more here.
Keywords: bdca2 adc; adc; bdca2; glucocorticoid responsive ... See more keywords