The Factor VIII Variant X5 Enhances Hemophilia a Gene Therapy Efficiency By Its Improved Secretion
Sign Up to like & getrecommendations! Published in 2019 at "Blood"
DOI: 10.1182/blood-2019-126489
Abstract: Introduction. Adeno-associated virus (AAV)-based factor VIII (FVIII) gene therapy holds great promise to provide clinical benefit in patients with hemophilia A. However, very high doses are currently needed to achieve therapeutic factor levels and the… read more here.
Keywords: baxalta innovations; fviii; gmbh takeda; innovations gmbh ... See more keywords
Anti-FVIII antibodies in Black and White hemophilia A subjects: do F8 haplotypes play a role?
Sign Up to like & getrecommendations! Published in 2022 at "Blood advances"
DOI: 10.1182/bloodadvances.2021004909
Abstract: The most common complication in hemophilia A (HA) treatment, affecting 25-30% of severe HA patients, is the development of alloimmune inhibitors that foreclose the ability of infused factor VIII (FVIII) to participate in coagulation. Inhibitors… read more here.
Keywords: anti fviii; fviii; bdd fviii; hemophilia ... See more keywords