CRCM5484: A BET-BDII Selective Compound with Differential Anti-leukemic Drug Modulation.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.1c02168
Abstract: Differentially screening the Fr-PPIChem chemical library on the bromodomain and extra-terminal (BET) BRD4-BDII versus -BDI bromodomains led to the discovery of a BDII-selective tetrahydropyridothienopyrimidinone (THPTP)-based compound. Structure-activity relationship (SAR) and hit-to-lead approaches allowed us to… read more here.
Keywords: bromodomain; drug; bdii selective; anti leukemic ... See more keywords