The BCKDH Kinase and Phosphatase Integrate BCAA and Lipid Metabolism via Regulation of ATP-Citrate Lyase.
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DOI: 10.1016/j.cmet.2018.04.015
Abstract: Branched-chain amino acids (BCAA) are strongly associated with dysregulated glucose and lipid metabolism, but the underlying mechanisms are poorly understood. We report that inhibition of the kinase (BDK) or overexpression of the phosphatase (PPM1K) that… read more here.
Keywords: citrate lyase; atp citrate; metabolism; lipid metabolism ... See more keywords