Curcumin prevents cognitive deficits in the bile duct ligated rats
Sign Up to like & getrecommendations! Published in 2020 at "Psychopharmacology"
DOI: 10.1007/s00213-020-05633-6
Abstract: Bile duct ligation (BDL) in rodents can cause impaired liver function and cognition deficits. Curcumin has shown a preventive and therapeutic role in memory impairment. Therefore, this study aimed to explore the effect of curcumin… read more here.
Keywords: function; bdl rats; bile duct; rats curcumin ... See more keywords
Mitochondrial dysfunctions contribute to energy deficits in rodent model of hepatic encephalopathy
Sign Up to like & getrecommendations! Published in 2017 at "Metabolic Brain Disease"
DOI: 10.1007/s11011-017-0136-8
Abstract: Perturbations in the cerebral energy metabolism are anticipated to be an important factor by which ammonia may exert its toxic effects on the central nervous system. The present study was designed to investigate the role… read more here.
Keywords: energy; bdl rats; cerebral energy; hepatic encephalopathy ... See more keywords
Blood-Brain Barrier Permeability Is Exacerbated in Experimental Model of Hepatic Encephalopathy via MMP-9 Activation and Downregulation of Tight Junction Proteins
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Neurobiology"
DOI: 10.1007/s12035-017-0521-7
Abstract: The present study was designed to investigate the mechanisms involved in blood-brain barrier (BBB) permeability in bile duct ligation (BDL) model of chronic hepatic encephalopathy (HE). Four weeks after BDL surgery, a significant increase was… read more here.
Keywords: bdl rats; permeability; expression; junction proteins ... See more keywords
Bile duct ligation enhances AZT CNS toxicity partly by impairing the expression and function of BCRP in rat brain
Sign Up to like & getrecommendations! Published in 2019 at "Acta Pharmacologica Sinica"
DOI: 10.1038/s41401-019-0242-8
Abstract: Breast cancer resistance protein (BCRP) is one of ATP-binding cassette (ABC) transporters in brain microvessel endothelial cells that transport their substrates from brain to blood, thus limiting substrates to crossing into brain through blood–brain barrier.… read more here.
Keywords: bcrp; brain; expression function; bdl rats ... See more keywords
Role of the cytochrome P-450/ epoxyeicosatrienoic acids pathway in the pathogenesis of renal dysfunction in cirrhosis
Sign Up to like & getrecommendations! Published in 2018 at "Nephrology Dialysis Transplantation"
DOI: 10.1093/ndt/gfx354
Abstract: Background Hepatorenal syndrome (HRS) is a life-threatening complication of advanced liver cirrhosis that is characterized by hemodynamic alterations in the kidney and other vascular beds. Cytochrome P(CYP)-450 enzymes metabolize arachidonic acid to epoxyeicosatrienoic acids (EETs)… read more here.
Keywords: renal dysfunction; epoxyeicosatrienoic acids; cirrhosis; bdl rats ... See more keywords
Sex is associated with differences in oxidative stress and susceptibility to severe hepatic encephalopathy in bile‐duct ligated rats
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Neurochemistry"
DOI: 10.1111/jnc.15661
Abstract: Hepatic encephalopathy (HE) is a debilitating neurological complication of chronic liver disease (CLD). Hyperammonemia plays an important role in HE's pathogenesis, acting synergistically with systemic oxidative stress. During CLD, muscle plays a compensatory role in… read more here.
Keywords: male bdl; bdl rats; oxidative stress; cld ... See more keywords
Effects of Intestinal FXR-Related Molecules on Intestinal Mucosal Barriers in Biliary Tract Obstruction
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.906452
Abstract: Background: The farnesoid X receptor (FXR) is a key factor regulating hepatic bile acid synthesis and enterohepatic circulation. Repression of bile acid synthesis by the FXR is a potential strategy for treating cholestatic liver disease.… read more here.
Keywords: intestinal microbiota; bdl rats; oca; intestinal fxr ... See more keywords
Rats with Long-Term Cholestasis Have a Decreased Cytosolic but Maintained Mitochondrial Hepatic CoA Pool
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24054365
Abstract: Previous studies showed that rats with long-term bile duct ligation have reduced coenzyme A stores per g of liver but maintained mitochondrial CoA stores. Based on these observations, we determined the CoA pool in the… read more here.
Keywords: liver; coa pool; bdl rats; pool ... See more keywords