Involvement of the BDNF–TrkB–KCC2 pathway in neuropathic pain after brachial plexus avulsion
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DOI: 10.1002/brb3.2464
Abstract: Brachial plexus avulsion significantly increased brain‐derived neurotrophic factor (BDNF) release in the spinal cord. Here we investigated the involvement of the BDNF–TrkB–KCC2 pathway in neuropathic pain caused by BPA injury. We hypothesized that activation of… read more here.
Keywords: brachial plexus; bdnf trkb; neuropathic pain; bdnf ... See more keywords
COX‐2/PGE2 axis regulates hippocampal BDNF/TrkB signaling via EP2 receptor after prolonged seizures
Sign Up to like & getrecommendations! Published in 2020 at "Epilepsia Open"
DOI: 10.1002/epi4.12409
Abstract: Abstract Objective The objective of this study was to identify the signaling pathway that is immediately triggered by status epilepticus (SE) and in turn contributes to the excessive brain‐derived neurotrophic factor (BDNF)/tropomyosin‐related kinase receptor B… read more here.
Keywords: trkb signaling; hippocampal bdnf; bdnf trkb; bdnf ... See more keywords
The role of BDNF methylation and Val66Met in amygdala reactivity during emotion processing
Sign Up to like & getrecommendations! Published in 2019 at "Human Brain Mapping"
DOI: 10.1002/hbm.24825
Abstract: Epigenetic alterations of the brain‐derived neurotrophic factor (BDNF) gene have been associated with psychiatric disorders in humans and with differences in amygdala BDNF mRNA levels in rodents. This human study aimed to investigate the relationship… read more here.
Keywords: methylation; amygdala reactivity; bdnf methylation; bdnf ... See more keywords
Global epigenetic analysis of BDNF Val66Met mice hippocampus reveals changes in dendrite and spine remodeling genes
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DOI: 10.1002/hipo.22991
Abstract: Brain‐derived neurotrophic factor (BDNF), a neurotrophin highly expressed in the hippocampus, plays crucial roles in cognition, neuroplasticity, synaptic function, and dendritic remodeling. The common human Val66Met polymorphism of BDNF has been implicated in the pathophysiology… read more here.
Keywords: analysis; bdnf val66met; mice; dendrite spine ... See more keywords
Sex differences and estrogen regulation of BDNF gene expression, but not propeptide content, in the developing hippocampus
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DOI: 10.1002/jnr.23920
Abstract: Sex differences in adult brain function are frequently determined developmentally through the actions of steroid hormones during sensitive periods of prenatal and early postnatal life. In rodents, various cellular end points of the developing brain… read more here.
Keywords: sex differences; gene expression; sex; expression ... See more keywords
Human BDNF rs6265 polymorphism as a mediator for the generalization of contextual anxiety
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Neuroscience Research"
DOI: 10.1002/jnr.24345
Abstract: The Met allele of the human brain‐derived neurotrophic factor (BDNF) gene might be a risk factor for anxiety disorders and is associated with reduced hippocampal volume. Notably, hippocampus plays a crucial role in contextual learning… read more here.
Keywords: generalization; anxiety; ctx; met allele ... See more keywords
BDNF‐overexpressing human mesenchymal stem cells mediate increased neuronal protection in vitro
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DOI: 10.1002/jnr.24488
Abstract: The use of neurotrophic factors as therapeutic agents for neurodegenerative diseases is considered as an approach aimed at restoring and maintaining neuronal function in the peripheral and central nervous system. Since the neuroprotective effect is… read more here.
Keywords: human mesenchymal; bdnf overexpressing; delivery; bdnf ... See more keywords
Neuroanatomical distribution and functions of brain‐derived neurotrophic factor in zebrafish (Danio rerio) brain
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DOI: 10.1002/jnr.24536
Abstract: Brain‐derived neurotrophic factor (BDNF) is an extensively studied protein that is evolutionarily conserved and widely distributed in the brain of vertebrates. It acts via its cognate receptors TrkB and p75NTR and plays a central role… read more here.
Keywords: brain derived; derived neurotrophic; neurotrophic factor; brain ... See more keywords
Dammarane sapogenins attenuates stress‐induced anxiety‐like behaviors by upregulating ERK/CREB/BDNF pathways
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DOI: 10.1002/ptr.6713
Abstract: Dammarane sapogenins (DS), an extract derived from ginseng by alkaline hydrolysis of total ginsenosides, possesses high pharmacological activity and higher bioavailability than ginsenosides. The present study was designed to investigate the anxiolytic‐like effects of DS… read more here.
Keywords: creb bdnf; anxiety like; creb; erk creb ... See more keywords
Dihydromyricetin exerts a rapid antidepressant-like effect in association with enhancement of BDNF expression and inhibition of neuroinflammation
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DOI: 10.1007/s00213-017-4761-z
Abstract: RationaleMajor depressive disorder (MDD) is a highly prevalent illness that affects large populations across the world, and increasing evidence suggests that neuroinflammation and levels of brain-derived neurotrophic factor (BDNF) are closely related to depression. Dihydromyricetin… read more here.
Keywords: depression; like effect; effect; antidepressant like ... See more keywords
Rottlerin, BDNF, and the impairment of inhibitory avoidance memory.
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DOI: 10.1007/s00213-020-05690-x
Abstract: RATIONALE AND OBJECTIVE As a eukaryotic elongation factor 2 kinase (eEF2K) inhibitor and a mitochondrial uncoupler, oncologists have extensively studied rottlerin. Neuroscientists, however, have accumulated scarce data on the role of rottlerin in affective and… read more here.
Keywords: consolidation; inhibitory avoidance; rottlerin; memory ... See more keywords