S-adenosylmethionine reduces the inhibitory effect of Aβ on BDNF expression through decreasing methylation level of BDNF exon Ⅳ in rats.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.12.166
Abstract: The structure of brain-derived neurotrophic factor (BDNF) gene is complex, which is composed of eight non-coding exons and one coding exon, each of them has its own unique promoter. Multiple BDNF transcripts have distinct functional… read more here.
Keywords: methylation; bdnf exon; bdnf expression; bdnf ... See more keywords
Gadd45α is involved in regulating activity-dependent and exon-specific BDNF expression in postmitotic cortical neurons
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DOI: 10.1097/wnr.0000000000001705
Abstract: Objective This study aimed to explore the epigenetic regulation of activity-dependent and exon-specific brain-derived neurotrophic factor (BDNF) expression under KCl depolarization in primary cortical neurons. Methods We investigated BDNF exon I, exon IV and the… read more here.
Keywords: bdnf; bdnf exon; expression; activity dependent ... See more keywords
BDNF Plasma Levels and BDNF Exon IV Promoter Methylation as Predictors for Antidepressant Treatment Response
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Psychiatry"
DOI: 10.3389/fpsyt.2018.00511
Abstract: Major problems of current antidepressant pharmacotherapy are insufficient response rates and difficulties in response prediction. We recently provided preliminary evidence in a small study that patients with major depressive disorder (MDD) with a hypomethylation of… read more here.
Keywords: early improvement; methylation; response; bdnf exon ... See more keywords