Edaravone Mitigates Hippocampal Neuronal Death and Cognitive Dysfunction by Upregulating BDNF Expression in Neonatal Hypoxic–Ischemic Rats
Sign Up to like & getrecommendations! Published in 2025 at "International Journal of Developmental Neuroscience"
DOI: 10.1002/jdn.10413
Abstract: Neonatal hypoxic–ischemic encephalopathy (HIE) is a severe neurological injury during infancy, often resulting in long‐term cognitive deficits. This study aimed to investigate the neuroprotective effects of Edaravone (EDA), a free radical scavenger, and elucidate the… read more here.
Keywords: hypoxic ischemic; hippocampal neuronal; bdnf expression; hie ... See more keywords
HIV-1 gp120 Upregulates Brain-Derived Neurotrophic Factor (BDNF) Expression in BV2 Cells via the Wnt/β-Catenin Signaling Pathway
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DOI: 10.1007/s12031-017-0931-z
Abstract: HIV-1 gp120 plays a critical role in the pathogenesis of HIV-associated pain, but the underlying molecular mechanisms are incompletely understood. This study aims to determine the effect and possible mechanism of HIV-1 gp120 on BDNF… read more here.
Keywords: catenin; gp120; bv2 cells; bdnf expression ... See more keywords
S-adenosylmethionine reduces the inhibitory effect of Aβ on BDNF expression through decreasing methylation level of BDNF exon Ⅳ in rats.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.12.166
Abstract: The structure of brain-derived neurotrophic factor (BDNF) gene is complex, which is composed of eight non-coding exons and one coding exon, each of them has its own unique promoter. Multiple BDNF transcripts have distinct functional… read more here.
Keywords: methylation; bdnf exon; bdnf expression; bdnf ... See more keywords
Identifying inducers of BDNF gene expression from pharmacologically validated compounds; antipyretic drug dipyrone increases BDNF mRNA in neurons.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2020.02.019
Abstract: Low levels of brain-derived neurotrophic factor (BDNF), a key regulator of synaptic plasticity, are associated with neurological diseases, including depression and Alzheimer's disease. Therefore, BDNF is a drug target for these diseases. Here we screened… read more here.
Keywords: dipyrone; drug; expression pharmacologically; expression ... See more keywords
Neonatal DEX exposure leads to hyperanxious and depressive-like behaviors as well as a persistent reduction of BDNF expression in developmental stages.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2020.04.084
Abstract: Brain-derived neurotrophic factor (BDNF), which regulates the neuronal survival, differentiation and synaptic plasticity, has been proved to play a critical role in the pathology and treatment of several psychiatric disorders including depression. Dexamethaone (DEX) is… read more here.
Keywords: dex; exposure leads; dex exposure; bdnf expression ... See more keywords
Amelioration of postoperative cognitive dysfunction in mice by mesenchymal stem cell-conditioned medium treatments is associated with reduced inflammation, oxidative stress and increased BDNF expression in brain tissues
Sign Up to like & getrecommendations! Published in 2019 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2019.134372
Abstract: OBJECTIVE Mesenchymal stem cells (MSCs) are widely used in regeneration and repair of various tissues and organs, and whether MSC-conditioned medium (MSC-CM) has protective effects in postoperative cognitive dysfunction (POCD) remains largely unknown. We aimed… read more here.
Keywords: mice; msc; bdnf expression; brain ... See more keywords
Chronic histamine 3 receptor antagonism alleviates depression like conditions in mice via modulation of brain-derived neurotrophic factor and hypothalamus-pituitary adrenal axis
Sign Up to like & getrecommendations! Published in 2019 at "Psychoneuroendocrinology"
DOI: 10.1016/j.psyneuen.2018.11.007
Abstract: The last two decades of research has established histamine (HA) as a neurotransmitter. Since H3R antagonists are known to modulate several neurotransmitters besides HA, H3R antagonists have shown potential for the treatment of different central… read more here.
Keywords: alleviates depression; histamine; expression; receptor ... See more keywords
GABAB receptor activation contributes to post-surgery cognitive impairments in mice by inducing hippocampal BDNF hypermethylation
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DOI: 10.1080/07853890.2025.2536221
Abstract: Abstract Background Clinical observations have shown that brain-derived neurotrophic factor (BDNF) expression is reduced in patients with impaired cognitive function after anaesthesia and surgery. Abnormal epigenetic changes may contribute to this condition. The role of… read more here.
Keywords: bdnf expression; bdnf; gabab receptor; receptor activation ... See more keywords
Mitogen- and stress-activated protein kinase-1 activation is involved in melanocortin-induced BDNF expression in Neuro2a neuronal cells
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DOI: 10.1097/wnr.0000000000001508
Abstract: Melanocortins are neuropeptides exerting versatile functions in the nervous system. Melanocortin 4 receptor (MC4R) is primarily expressed in the brain and is thought to be a major mediator for melanocortin. Brain-derived neurotrophic factor (BDNF) may… read more here.
Keywords: bdnf; expression; activation; neuronal cells ... See more keywords
TPPU Downregulates Oxidative Stress Damage and Induces BDNF Expression in PC-12 Cells
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DOI: 10.1155/2022/7083022
Abstract: Objective Ischemia-reperfusion is an ongoing clinical challenge that can lead to a series of pathological changes including oxidative stress. The inhibition of soluble epoxide hydrolase inhibitor (sEH) by 1-(1-propanoylpiperidin-4-yl)-3-[4-(trifluoromethoxy)phenyl]urea (TPPU) results in an anti-inflammatory, cardioprotective,… read more here.
Keywords: cell; oxidative stress; expression; bdnf expression ... See more keywords
H3K9me2 regulation of BDNF expression via G9a partakes in the progression of heart failure
Sign Up to like & getrecommendations! Published in 2022 at "BMC Cardiovascular Disorders"
DOI: 10.1186/s12872-022-02621-w
Abstract: Background Heart disease is a major cause of mortality in developed countries. The associated pathology is mainly characterized by the loss of cardiomyocytes that contributes to heart failure (HF). This study aims to investigate the… read more here.
Keywords: bdnf; bdnf expression; heart failure; g9a ... See more keywords