Involvement of the BDNF–TrkB–KCC2 pathway in neuropathic pain after brachial plexus avulsion
Sign Up to like & getrecommendations! Published in 2022 at "Brain and Behavior"
DOI: 10.1002/brb3.2464
Abstract: Brachial plexus avulsion significantly increased brain‐derived neurotrophic factor (BDNF) release in the spinal cord. Here we investigated the involvement of the BDNF–TrkB–KCC2 pathway in neuropathic pain caused by BPA injury. We hypothesized that activation of… read more here.
Keywords: brachial plexus; bdnf trkb; neuropathic pain; bdnf ... See more keywords
COX‐2/PGE2 axis regulates hippocampal BDNF/TrkB signaling via EP2 receptor after prolonged seizures
Sign Up to like & getrecommendations! Published in 2020 at "Epilepsia Open"
DOI: 10.1002/epi4.12409
Abstract: Abstract Objective The objective of this study was to identify the signaling pathway that is immediately triggered by status epilepticus (SE) and in turn contributes to the excessive brain‐derived neurotrophic factor (BDNF)/tropomyosin‐related kinase receptor B… read more here.
Keywords: trkb signaling; hippocampal bdnf; bdnf trkb; bdnf ... See more keywords
Neuroplastic changes in c‐Fos, ΔFosB, BDNF, trkB, and Arc expression in the hippocampus of male Roman rats: differential effects of sexual activity
Sign Up to like & getrecommendations! Published in 2022 at "Hippocampus"
DOI: 10.1002/hipo.23448
Abstract: Sexual activity causes differential changes in the expression of markers of neural activation (c‐Fos and ΔFosB) and neural plasticity (Arc and BDNF/trkB), as determined either by Western Blot (BDNF, trkB, Arc, and ΔFosB) or immunohistochemistry… read more here.
Keywords: bdnf trkb; sexual activity; activity; trkb arc ... See more keywords
Imperatorin ameliorates learning and memory deficits through BDNF/TrkB and ERK/CaMKIIα/CREB signaling in prenatally‐stressed female offspring
Sign Up to like & getrecommendations! Published in 2020 at "Phytotherapy Research"
DOI: 10.1002/ptr.6692
Abstract: Prenatal stress (PS) can lead to impaired spatial learning and memory in offspring. Imperatorin (IMP) is a naturally occurring furanocoumarin with many pharmacological properties. However, the effects of IMP on cognitive impairment induced by PS… read more here.
Keywords: learning memory; camkii creb; bdnf trkb; memory deficits ... See more keywords
Tanshinone IIA improves contextual fear‐ and anxiety‐like behaviors in mice via the CREB/BDNF/TrkB signaling pathway
Sign Up to like & getrecommendations! Published in 2022 at "Phytotherapy Research"
DOI: 10.1002/ptr.7540
Abstract: Posttraumatic stress disorder (PTSD) is one of the most common psychiatric diseases, which is characterized by the typical symptoms such as re‐experience, avoidance, and hyperarousal. However, there are few drugs for PTSD treatment. In this… read more here.
Keywords: bdnf trkb; tanshinone iia; creb bdnf;
Isoflurane produces antidepressant effects inducing BDNF-TrkB signaling in CUMS mice
Sign Up to like & getrecommendations! Published in 2019 at "Psychopharmacology"
DOI: 10.1007/s00213-019-05287-z
Abstract: RationaleThe volatile anesthetic isoflurane is suggested to produce a rapid and robust antidepressive effect in preliminary clinical trials. Recently, isoflurane was found to activate the tropomyosin receptor kinase B (TrkB) signaling which is the underlying… read more here.
Keywords: trkb signaling; effect; bdnf trkb; isoflurane ... See more keywords
Berberine Ameliorates MCAO Induced Cerebral Ischemia/Reperfusion Injury via Activation of the BDNF–TrkB–PI3K/Akt Signaling Pathway
Sign Up to like & getrecommendations! Published in 2018 at "Neurochemical Research"
DOI: 10.1007/s11064-018-2472-4
Abstract: Cerebral ischemic injury remains associated with high mortality rates and lacks effective therapeutic intervention. Berberine (BBR) possesses anti-oxidant, anti-inflammatory, and anti-tumor activities, as well as potent neuroprotective effects. Although recent studies have examined the neuroprotective… read more here.
Keywords: injury; pi3k; bdnf trkb; bbr ... See more keywords
Absence of Carboxypeptidase E/Neurotrophic Factor-Α1 in Knock-Out Mice Leads to Dysfunction of BDNF-TRKB Signaling in Hippocampus
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Molecular Neuroscience"
DOI: 10.1007/s12031-017-0914-0
Abstract: Carboxypeptidase E (CPE), first discovered as a prohormone processing enzyme, has also now been shown to be a secreted neurotrophic factor (neurotrophic factor-α1, NF-α1) that acts extracellularly as a signaling molecule to mediate neuroprotection, cortical… read more here.
Keywords: trkb signaling; bdnf trkb; mice; neurotrophic factor ... See more keywords
Melatonin improves learning and memory of mice with chronic social isolation stress via an interaction between microglia polarization and BDNF/TrkB/CREB signaling pathway.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2021.174358
Abstract: Chronic social isolation stress (SIS) could impair learning and memory-related behaviors. Herein, we investigated the efficacy of Melatonin in treatment of memory despair and also its possible underlying mechanism of action in an animal model… read more here.
Keywords: creb; bdnf trkb; mice; isolation ... See more keywords
Crosstalk between the muscular estrogen receptor α and BDNF/TrkB signaling alleviates metabolic syndrome via 7,8-dihydroxyflavone in female mice.
Sign Up to like & getrecommendations! Published in 2020 at "Molecular metabolism"
DOI: 10.1016/j.molmet.2020.101149
Abstract: OBJECTIVE 7,8-Dihydroxyflavone (7,8-DHF), a small molecular mimetic of brain derived neurotrophic factor (BDNF), alleviates high-fat diet-induced obesity of female mice in a sex-specific manner by activating muscular tropomyosin-related kinase B (TrkB). However, the underlying molecular… read more here.
Keywords: trkb signaling; trkb; bdnf trkb; sex ... See more keywords
Sympathetic nervous remodeling is induced in the intermediolateral nucleus after myocardial infarction – Role of BDNF-TrkB axis-
Sign Up to like & getrecommendations! Published in 2018 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2018.08.004
Abstract: Several studies have shown that neural remodeling in stellate ganglia (SG) is induced by myocardial infarction (MI). It remains unclear whether neural remodeling after MI is limited in SG within the sympathetic nervous system (SNS).… read more here.
Keywords: sympathetic nervous; myocardial infarction; neural remodeling; bdnf trkb ... See more keywords