The Chiral Bioconversion and Pharmacokinetic Analysis of Trelagliptin in Beagle Dog Plasma by LC-MS/MS.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of chromatographic science"
DOI: 10.1093/chromsci/bmz105
Abstract: A simple and enantioselective method was developed and validated for the simultaneous determination of (R)- and (S)-trelagliptin in beagle dog plasma by chiral liquid chromatography tandem mass spectrometry. Trelagliptin enantiomers and (R)-rabeprazole (as internal standard,… read more here.
Keywords: trelagliptin beagle; beagle dog; trelagliptin; dog plasma ... See more keywords
Hepatic Organic Anion Transporting Polypeptide–Mediated Clearance in the Beagle Dog: Assessing In Vitro–In Vivo Relationships and Applying Cross-Species Empirical Scaling Factors to Improve Prediction of Human Clearance
Sign Up to like & getrecommendations! Published in 2018 at "Drug Metabolism and Disposition"
DOI: 10.1124/dmd.118.084194
Abstract: In the present study, the beagle dog was evaluated as a preclinical model to investigate organic anion transporting polypeptide (OATP)–mediated hepatic clearance. In vitro studies were performed with nine OATP substrates in three lots of… read more here.
Keywords: anion transporting; beagle dog; clearance; organic anion ... See more keywords
Interstitial Adipocytes in the Beagle Dog and New Zealand White Rabbit Choroid Plexus
Sign Up to like & getrecommendations! Published in 2019 at "Toxicologic Pathology"
DOI: 10.1177/0192623319839916
Abstract: The choroid plexus (CP) produces cerebrospinal fluid and has epithelial, interstitial, and vascular compartments. The CP is a potential site of toxicity, and recognizing the normal microanatomy in different animal models is important for the… read more here.
Keywords: new zealand; choroid plexus; dog new; beagle dog ... See more keywords
Effects of combination treatment with alendronate and raloxifene on skeletal properties in a beagle dog model
Sign Up to like & getrecommendations! Published in 2017 at "PLoS ONE"
DOI: 10.1371/journal.pone.0181750
Abstract: A growing number of studies have investigated combination treatment as an approach to treat bone disease. The goal of this study was to investigate the combination of alendronate and raloxifene with a particular focus on… read more here.
Keywords: treatment; beagle dog; combination treatment; model ... See more keywords