The 14‐day repeated‐dose toxicity study of a fixed‐dose combination, QXOH/levobupivacaine, via subcutaneous injection in beagle dogs
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Applied Toxicology"
DOI: 10.1002/jat.4111
Abstract: QXOH‐Levobupivacaine (LB) is a fixed‐dose combination of 35‐mM QXOH and 10‐mM LB. It was developed for perioperative analgesia because of its long‐acting analgesic effect. The purpose of this study was to evaluate the potential toxicity… read more here.
Keywords: fixed dose; qxoh qxoh; qxoh levobupivacaine; beagle dogs ... See more keywords
28‐day repeated dose toxicity and toxicokinetics study on new melatonergic antidepressant GW117 in beagle dogs
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Applied Toxicology"
DOI: 10.1002/jat.4407
Abstract: GW117 is new melatonergic antidepressant being developed to show better antidepressant action than agomelatine. The purpose of this study was to evaluate the toxicity and to determine potential target organs after oral (gavage) administration of… read more here.
Keywords: day; melatonergic antidepressant; gw117; beagle dogs ... See more keywords
Investigation of a novel brachytherapy ureteral stent: trial studies on normal beagle dogs
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Cancer Research and Clinical Oncology"
DOI: 10.1007/s00432-021-03513-w
Abstract: To evaluate the safety and feasibility of a newly designed 125I brachytherapy ureteral stent (BUS) in normal dogs. A BUS loaded with 10 125I seeds (Group A: 0.8 mCi, Group B: 0.4 mCi, Group C:… read more here.
Keywords: ureteral stent; normal beagle; beagle dogs; group ... See more keywords
Effects of Queso Blanco cheese containing Bifidobacterium longum KACC 91563 on fecal microbiota, metabolite and serum cytokine in healthy beagle dogs.
Sign Up to like & getrecommendations! Published in 2020 at "Anaerobe"
DOI: 10.1016/j.anaerobe.2020.102234
Abstract: The study describes the effects of administration of Queso Blanco cheese containing Bifidobacterium longum on the fecal microbiota, metabolite and serum cytokine in healthy beagle dogs. Twelve healthy beagle dogs were randomly divided in three… read more here.
Keywords: queso blanco; beagle dogs; blanco cheese; fecal microbiota ... See more keywords
Characterization of the GI transit conditions in Beagle dogs with a telemetric motility capsule
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Pharmaceutics and Biopharmaceutics"
DOI: 10.1016/j.ejpb.2019.01.026
Abstract: Graphical abstract Figure. No Caption available. ABSTRACT In preclinical research, Beagle dogs are an important model for formulation development and for evaluation of food effects on drug absorption. In this study, the gastrointestinal transit conditions… read more here.
Keywords: conditions beagle; transit; beagle dogs; motility capsule ... See more keywords
Metabolite‐inactive etomidate analogues alleviating suppression on adrenal function in Beagle dogs
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Pharmaceutical Sciences"
DOI: 10.1016/j.ejps.2016.12.041
Abstract: Abstract Owing to rapid generation in body, the metabolites of etomidate softdrug are able to accumulate in either the brain or periphery and subsequently affect the recovery from anaesthesia or cause corticosteroid suppression. This study… read more here.
Keywords: etomidate; suppression; beagle dogs; metabolite inactive ... See more keywords
Double controlled release of highly insoluble cilostazol using surfactant‐driven pH dependent and pH‐independent polymeric blends and in vivo bioavailability in beagle dogs
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Pharmaceutics"
DOI: 10.1016/j.ijpharm.2019.01.004
Abstract: ABSTRACT Commercially available cilostazol (CIL) tablet releases drug immediately and is given twice a day as an antiplatelet and vasodilatory agent. However, clinical usefulness of immediate release (IR) preparation is limited due to its extremely… read more here.
Keywords: controlled release; beagle dogs; polymeric blends; double controlled ... See more keywords
Changes of electrocardiogram and hemodynamics in response to dipyridamole: In vivo comparative analyses using anesthetized beagle dogs and microminipigs.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of pharmacological sciences"
DOI: 10.1016/j.jphs.2018.01.002
Abstract: Microminipigs are expected as a novel animal model for cardiovascular pharmacological experiments. Since inherent vulnerability of coronary circulation of microminipigs has not been characterized, we performed dipyridamole-stress test to both microminipigs and beagle dogs, and… read more here.
Keywords: electrocardiogram hemodynamics; changes electrocardiogram; hemodynamics response; beagle dogs ... See more keywords
Enhanced Bone Remodeling Effects of Low-Modulus Ti–5Zr–3Sn–5Mo–25Nb Alloy Implanted in the Mandible of Beagle Dogs under Delayed Loading
Sign Up to like & getrecommendations! Published in 2019 at "ACS Omega"
DOI: 10.1021/acsomega.9b02580
Abstract: Titanium (Ti) and its alloys are widely used in the dental and prosthetic implant fields due to their favorable biocompatibility. In this study, porous surface coatings incorporated with nanoscale hydroxyapatite particles on the surface of… read more here.
Keywords: alloy; 5zr 3sn; beagle dogs; bone ... See more keywords
Plasma metabolomic analysis in mature female common bottlenose dolphins: profiling the characteristics of metabolites after overnight fasting by comparison with data in beagle dogs
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-30563-x
Abstract: The present study was aimed at determining the characteristics of plasma metabolites in bottlenose dolphins to provide a greater understanding of their metabolism and to obtain information for the health management of cetaceans. Capillary electrophoresis-time-of-flight… read more here.
Keywords: common bottlenose; analysis; beagle dogs; overnight fasting ... See more keywords
Pharmacokinetics and Safety of Mitragynine in Beagle Dogs.
Sign Up to like & getrecommendations! Published in 2020 at "Planta medica"
DOI: 10.1055/a-1212-5475
Abstract: Mitragynine is the most abundant psychoactive alkaloid derived from the leaves of Mitragyna speciosa (kratom), a tropical plant indigenous to regions of Southeast Asia. Mitragynine displays a moderate affinity to opioid receptors, and kratom is… read more here.
Keywords: mitragynine beagle; mitragynine; beagle dogs; safety mitragynine ... See more keywords