Identification of hydrazone moiety-bearing aminopyrimidines as potent antitumor agents with selective inhibition of gefitinib-resistant H1975 cancer cells
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DOI: 10.1016/j.cclet.2016.11.030
Abstract: Abstract Based on our previous work, a series of hydrazone moiety-bearing aminopyrimidines were synthesized. The compounds were evaluated for inhibitory activities against EGFR T790M/L858R and antiproliferative activities against H1975 and A549 NSCLC cell lines harboring… read more here.
Keywords: moiety bearing; bearing aminopyrimidines; cancer cells; inhibition gefitinib ... See more keywords