Synthesis and Pharmacological Activities of Chalcone and Its Derivatives Bearing N-Heterocyclic Scaffolds: A Review
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DOI: 10.1021/acsomega.3c01035
Abstract: The incorporation of heterocyclic moieties into the standard chemical structure with a biologically active scaffold has become of crucial practice for the construction of pharmacologically potent candidates in the drug arena. Currently, numerous kinds of… read more here.
Keywords: chalcone derivatives; bearing heterocyclic; pharmacological activities; heterocyclic scaffolds ... See more keywords
Synthesis of Novel 1-Oxo-2,3,4-trisubstituted Tetrahydroisoquinoline Derivatives, Bearing Other Heterocyclic Moieties and Comparative Preliminary Study of Anti-Coronavirus Activity of Selected Compounds
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DOI: 10.3390/molecules28031495
Abstract: A series of novel 1-oxo-2,3,4-trisubstituted tetrahydroisoquinoline (THIQ) derivatives bearing other heterocyclic moieties in their structure were synthesized based on the reaction between homophthalic anhydride and imines. Initial studies were carried out to establish the anti-coronavirus… read more here.
Keywords: trisubstituted tetrahydroisoquinoline; bearing heterocyclic; novel oxo; oxo trisubstituted ... See more keywords
MW-9, a chalcones derivative bearing heterocyclic moieties, attenuates experimental autoimmune encephalomyelitis via suppressing pathogenic TH17 cells
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DOI: 10.3892/mmr.2022.12824
Abstract: Previous studies have indicated that MW-9, a chalcones derivative bearing heterocyclic moieties, has considerable anti-inflammatory activity in vitro. Whether MW-9 may be used to treat inflammation-based diseases, such as multiple sclerosis, remains unknown. The present… read more here.
Keywords: derivative bearing; th17 cells; chalcones derivative; bearing heterocyclic ... See more keywords