Design, Synthesis, Characterization, and Antimicrobial Screening of Novel Indazole Bearing Oxadiazole Derivatives
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Heterocyclic Chemistry"
DOI: 10.1002/jhet.2540
Abstract: Ethyl 2-(2,6-dioxocyclohexyl)-2-oxoacetate was prepared by reacting cyclohexane-1,3-dione (1) and diethyl oxalate (2) with the help of sodium ethoxide in ethanol at 0–5°C. Subsequent treatment of ethyl 2-(2,6-dioxocyclohexyl)-2-oxoacetate with hydrazine hydrate in ethanol resulted into ethyl… read more here.
Keywords: oxadiazole derivatives; novel indazole; bearing oxadiazole; indazole bearing ... See more keywords
Synthesis and antifungal activities of novel thiophene-based stilbene derivatives bearing an 1,3,4-oxadiazole unit.
Sign Up to like & getrecommendations! Published in 2019 at "Pest management science"
DOI: 10.1002/ps.5229
Abstract: BACKGROUND Natural stilbenes (especially resveratrol and its derivatives) are well-known phytoalexins that are active against many plant diseases. However, oxidative degradation and low bioavailability limit their exogenous application as fungicides on crops. In this study,… read more here.
Keywords: derivatives bearing; based stilbene; thiophene; thiophene based ... See more keywords
Synthesis and Evaluation of Biological Activity of Homodrimane Sesquiterpenoids Bearing 1,3,4-Oxadiazole or 1,3,4-Thiadiazole Units
Sign Up to like & getrecommendations! Published in 2020 at "Chemistry of Heterocyclic Compounds"
DOI: 10.1007/s10593-020-02703-7
Abstract: Synthesis of novel (+)-sclareolide-based homodrimane sesquiterpenoids bearing 1,3,4-oxadiazole or 1,3,4-thiadiazole units has been reported. These terpeno-heterocyclic compounds demonstrate promising antifungal and antibacterial activities toward fungal species Aspergillus niger , Fusarium solani , Penicillium chrysogenum ,… read more here.
Keywords: oxadiazole thiadiazole; sesquiterpenoids bearing; bearing oxadiazole; thiadiazole units ... See more keywords
New potential biologically active compounds: Synthesis and characterization of urea and thiourea derivatives bearing 1,2,4-oxadiazole ring.
Sign Up to like & getrecommendations! Published in 2020 at "Current organic synthesis"
DOI: 10.2174/1570179417666200417112106
Abstract: BACKGROUND Urea, thiourea, and 1,2,4-oxadiazole compounds are of great interest due to their different activities such as anti-inflammatory, antiviral, analgesic, fungicidal, herbicidal, diuretic, antihelminthic and antitumor along with antimicrobial activities. OBJECTIVE In this work, we… read more here.
Keywords: oxadiazole ring; potential biologically; bearing oxadiazole; urea thiourea ... See more keywords
Pyrimido[4,5-b]indole derivatives bearing 1,2,4-oxadiazole moiety as MDM2 inhibitor candidates in cancer treatment.
Sign Up to like & getrecommendations! Published in 2023 at "Future medicinal chemistry"
DOI: 10.4155/fmc-2023-0012
Abstract: Aim: In this study, novel hybrid structures of pyrimido-indole-oxadiazole were developed as MDM2 inhibitors for restoring the regular function of the p53. Materials & methods: A multistep chemical pathway was used to synthesize the derivatives.… read more here.
Keywords: mdm2; indole derivatives; bearing oxadiazole; derivatives bearing ... See more keywords