Discovery of potent and highly selective covalent inhibitors of Bruton's tyrosine kinase bearing triazine scaffold.
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DOI: 10.1016/j.ejmech.2020.112339
Abstract: Bruton's tyrosine kinase (BTK), as a key regulator of the B cell receptor (BCR) signaling pathway, is an attractive therapeutic target for the treatment of various diseases such as leukemia and B-cell malignancies. Herein, a… read more here.
Keywords: bearing triazine; discovery potent; kinase; btk ... See more keywords