The Class I PI3K inhibitor S14161 induces autophagy in malignant blood cells by modulating the Beclin 1/Vps34 complex.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of pharmacological sciences"
DOI: 10.1016/j.jphs.2017.07.001
Abstract: S14161 is a pan-Class I PI3K inhibitor that induces blood cancer cell death, but its mechanism is largely unknown. In the present study, we evaluated the role of S14161 in autophagy, an emerging event in… read more here.
Keywords: s14161; pi3k inhibitor; beclin; class pi3k ... See more keywords
High-Throughput Screens To Identify Autophagy Inducers That Function by Disrupting Beclin 1/Bcl-2 Binding.
Sign Up to like & getrecommendations! Published in 2018 at "ACS chemical biology"
DOI: 10.1021/acschembio.8b00421
Abstract: Autophagy, a lysosomal degradation pathway, plays a crucial role in cellular homeostasis, development, immunity, tumor suppression, metabolism, prevention of neurodegeneration, and lifespan extension. Thus, pharmacological stimulation of autophagy may be an effective approach for preventing… read more here.
Keywords: beclin; bcl binding; beclin bcl; autophagy ... See more keywords
Tamoxifen overrides autophagy inhibition in Beclin-1-deficient glioma cells and their resistance to adenovirus-mediated oncolysis via upregulation of PUMA and BAX
Sign Up to like & getrecommendations! Published in 2018 at "Oncogene"
DOI: 10.1038/s41388-018-0395-9
Abstract: Autophagy is an evolutionarily conserved process regulating cellular homeostasis via digestion of dysfunctional proteins and whole cellular organelles by mechanisms, involving their enclosure into double-membrane vacuoles that are subsequently fused to lysosomes. Glioma stem cells… read more here.
Keywords: via upregulation; glioma; deficient; beclin ... See more keywords
Disruption of the beclin 1/Bcl-2 autophagy regulatory complex promotes longevity in mice
Sign Up to like & getrecommendations! Published in 2018 at "Nature"
DOI: 10.1038/s41586-018-0162-7
Abstract: Autophagy increases the lifespan of model organisms; however, its role in promoting mammalian longevity is less well-established1,2. Here we report lifespan and healthspan extension in a mouse model with increased basal autophagy. To determine the… read more here.
Keywords: longevity; beclin; disruption beclin; bcl2 ... See more keywords
Nuclear localization of Beclin 1 promotes radiation-induced DNA damage repair independent of autophagy
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/srep45385
Abstract: Beclin 1 is a well-established core mammalian autophagy protein that is embryonically indispensable and has been presumed to suppress oncogenesis via an autophagy-mediated mechanism. Here, we show that Beclin 1 is a prenatal primary cytoplasmic… read more here.
Keywords: dna damage; beclin; repair independent; repair ... See more keywords
A6799 Ginsenoside Rb1 alleviate ox-LDL induced HUVEC senescence via SIRT1/Beclin-1/autophagy axis
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Hypertension"
DOI: 10.1097/01.hjh.0000548181.15339.f0
Abstract: Objectives: Our previous studies have proved that ginsenoside Rb1 (gRb1) prevent H2O2 induced HUVECs senescence through SIRT1/eNOS/ROS axis. This study is to explore the effect of gRb1 on ox-LDL induced HUVECs senescence and the role… read more here.
Keywords: sirt1 beclin; beclin; senescence; autophagy ... See more keywords
Role of autophagy and its molecular mechanisms in mice intestinal tract after severe burn.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Trauma and Acute Care Surgery"
DOI: 10.1097/ta.0000000000001624
Abstract: BACKGROUND Severe burn can lead to hypoxia/ischemia of intestinal mucosa. Autophagy is the process of intracellular degradation, which is essential for cell survival under stresses such as hypoxia/ischemia and nutrient deprivation. The present study was… read more here.
Keywords: burn; beclin; intestinal autophagy; molecular mechanisms ... See more keywords
Blue LED causes autophagic cell death in human osteosarcoma by increasing ROS generation and dephosphorylating EGFR
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.16412
Abstract: Osteosarcoma (OS) is the most common primary malignant bone tumour in adolescence. Lately, light‐emitting diodes (LED)‐based therapy has emerged as a new promising approach for several diseases. However, it remains unknown in human OS. Here,… read more here.
Keywords: autophagic cell; blue led; beclin; led irradiation ... See more keywords
FRI0512 RETRO-INVERSO TAT-BECLIN-1 INDUCES SYNOVIAL FIBROSIS AND DOES NOT PROTECT CARTILAGE FROM DEGENERATION IN A MOUSE MODEL OF OA
Sign Up to like & getrecommendations! Published in 2019 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2019-eular.2680
Abstract: Background Beclin-1 is a component of the autophagy pathway necessary for formation of autophagosomes, contributing to autophagy-mediated cellular homeostasis. Enhancing autophagy through inhibition of mTOR activity, either via genetic deletion in chondrocytes or intra-articular injection… read more here.
Keywords: inverso tat; beclin; retro inverso; tat beclin ... See more keywords
Cantharidin Inhibits the Growth of Triple-Negative Breast Cancer Cells by Suppressing Autophagy and Inducing Apoptosis in Vitro and in Vivo
Sign Up to like & getrecommendations! Published in 2017 at "Cellular Physiology and Biochemistry"
DOI: 10.1159/000484069
Abstract: Background/Aims: Cantharidin, a type of terpenoid secreted by the blister beetle Mylabris phalerata (Pallas), has attracted great attention in cancer therapy because of its potential anti-cancer activities. Here, we report the effects on apoptosis and… read more here.
Keywords: inducing apoptosis; apoptosis; beclin; cantharidin ... See more keywords
Beclin-1-Dependent Autophagy Protects the Heart During Sepsis
Sign Up to like & getrecommendations! Published in 2018 at "Circulation"
DOI: 10.1161/circulationaha.117.032821
Abstract: Background: Cardiac dysfunction is a major component of sepsis-induced multiorgan failure in critical care units. Changes in cardiac autophagy and its role during sepsis pathogenesis have not been clearly defined. Targeted autophagy-based therapeutic approaches for… read more here.
Keywords: sepsis; beclin dependent; beclin; heart sepsis ... See more keywords