Prediction of post translation modifications at the contact site between Anaplasma phagocytophilum and human host during autophagosome induction using a bioinformatic approach.
Sign Up to like & getrecommendations! Published in 2017 at "Molecular and cellular probes"
DOI: 10.1016/j.mcp.2016.09.002
Abstract: Autophagy is crucial for maintaining physiological homeostasis, but its role in infectious diseases is not yet adequately understood. The binding of Anaplasma translocated substrate-1 (ATS1) to the human Beclin1 (BECN1) protein is responsible for the… read more here.
Keywords: becn1; autophagosome induction; anaplasma phagocytophilum;
Diethylstilbestrol (DES) induces autophagy in thymocytes by regulating Beclin-1 expression through epigenetic modulation.
Sign Up to like & getrecommendations! Published in 2018 at "Toxicology"
DOI: 10.1016/j.tox.2018.08.012
Abstract: Diethylstilbestrol (DES) is an endocrine disruptor that was used to prevent adverse effects of pregnancy in women in late 1940s until early 1970s. Its use was banned following significant toxicity and negative effects not only… read more here.
Keywords: des induces; autophagy thymocytes; expression; induces autophagy ... See more keywords
HIV-1 Nef counteracts autophagy restriction by enhancing the association between BECN1 and its inhibitor BCL2 in a PRKN-dependent manner
Sign Up to like & getrecommendations! Published in 2020 at "Autophagy"
DOI: 10.1080/15548627.2020.1725401
Abstract: ABSTRACT Macroautophagy/autophagy is an auto-digestive pro-survival pathway activated in response to stress to target cargo for lysosomal degradation. In recent years, autophagy has become prominent as an innate antiviral defense mechanism through multiple processes, such… read more here.
Keywords: restriction; hiv; enhancing association; prkn ... See more keywords
FoxO1‐AMPK‐ULK1 Regulates Ethanol‐Induced Autophagy in Muscle by Enhanced ATG14 Association with the BECN1‐PIK3C3 Complex
Sign Up to like & getrecommendations! Published in 2017 at "Alcoholism: Clinical and Experimental Research"
DOI: 10.1111/acer.13377
Abstract: BACKGROUND Excessive alcohol (EtOH) consumption causes an imbalance in protein metabolism. EtOH impairs protein synthesis in C2C12 myoblasts via a FoxO1-AMPK-TSC2-mTORC1 pathway and also induces protein degradation. As the underlying regulatory signaling cascades for these… read more here.
Keywords: pik3c3 complex; foxo1 ampk; pik3c3; becn1 ... See more keywords
Hsa_circ_0020850 promotes the malignant behaviors of lung adenocarcinoma by regulating miR-326/BECN1 axis
Sign Up to like & getrecommendations! Published in 2022 at "World Journal of Surgical Oncology"
DOI: 10.1186/s12957-021-02480-3
Abstract: Background Circular RNAs (circRNAs) are a novel type of endogenous RNAs and play vital roles in lung adenocarcinoma. However, the function and underlying mechanism of circ_0020850 in lung adenocarcinoma remain unknown. Methods The levels of… read more here.
Keywords: circ 0020850; becn1; lung adenocarcinoma; mir 326 ... See more keywords
A Becn1 mutation mediates hyperactive autophagic sequestration of amyloid oligomers and improved cognition in Alzheimer's disease
Sign Up to like & getrecommendations! Published in 2017 at "PLoS Genetics"
DOI: 10.1371/journal.pgen.1006962
Abstract: Impairment of the autophagy pathway has been observed during the pathogenesis of Alzheimer’s disease (AD), a neurodegenerative disorder characterized by abnormal deposition of extracellular and intracellular amyloid β (Aβ) peptides. Yet the role of autophagy… read more here.
Keywords: becn1; alzheimer disease; autophagy; amyloid oligomers ... See more keywords
Depletion of Adipocyte Becn1 Leads to Lipodystrophy and Metabolic Dysregulation
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DOI: 10.2337/db19-1239
Abstract: Becn1/Beclin-1 is a core component of the class III phosphatidylinositol 3-kinase required for autophagosome formation and vesicular trafficking. Although Becn1 has been implicated in numerous diseases such as cancer, aging, and neurodegenerative disease, the role… read more here.
Keywords: depletion adipocyte; adipocyte becn1; adipocyte; adipose tissue ... See more keywords
BECN1 protein expression is associated with poor survival in triple negative locally advanced breast cancer.
Sign Up to like & getrecommendations! Published in 2022 at "European review for medical and pharmacological sciences"
DOI: 10.26355/eurrev_202201_27860
Abstract: OBJECTIVE The role that Beclin 1 (BECN1) plays in the development and progression of cancer mediated by autophagy, as well as its differential expression in breast cancer cell lines and mammary tumor tissue according to… read more here.
Keywords: triple negative; breast cancer; expression; becn1 ... See more keywords
SHP-1/STAT3-Signaling-Axis-Regulated Coupling between BECN1 and SLC7A11 Contributes to Sorafenib-Induced Ferroptosis in Hepatocellular Carcinoma
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms231911092
Abstract: Ferroptosis is a type of iron-dependent cell death pertaining to an excess of lipid peroxidation. It has been suggested that sorafenib—an anti-angiogenic medication for hepatocellular carcinoma (HCC)—induces ferroptosis, but the underlying mechanism for this remains… read more here.
Keywords: hepatocellular carcinoma; shp stat3; slc7a11; becn1 slc7a11 ... See more keywords
Reduced-Beclin1-Expressing Mice Infected with Zika-R103451 and Viral-Associated Pathology during Pregnancy
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DOI: 10.3390/v12060608
Abstract: Here, we used a mouse model with defective autophagy to further decipher the role of Beclin1 in the infection and disease of Zika virus (ZIKV)-R103451. Hemizygous (Becn1+/−) and wild-type (Becn1+/+) pregnant mice were transiently immunocompromised… read more here.
Keywords: reduced beclin1; pathology; expression; mice ... See more keywords
Deregulation of the Expression of Beclin1 and Light Chain 3(LC3), Autophagy-Related Genes, in COVID-19 Patients
Sign Up to like & getrecommendations! Published in 2022 at "Medical Journal of the Islamic Republic of Iran"
DOI: 10.47176/mjiri.36.99
Abstract: Background: The autophagy machinery is reported to be employed by Coronaviruses during their replication. Beclin-1 (BECN1) and protein 1 light chain 3 (LC3) are two key elements in the autophagy process, and their inhibition can… read more here.
Keywords: covid patients; expression; chain lc3; light chain ... See more keywords