Discovery of Anti‐tubercular Analogues of Bedaquiline with Modified A‐, B‐ and C‐Ring Subunits
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DOI: 10.1002/cmdc.202200533
Abstract: To date, the clinical use of the anti‐tubercular therapy bedaquiline has been somewhat limited due to safety concerns. Recent investigations determined that modification of the B‐ and C‐ring units of bedaquiline delivered new diarylquinolines (for… read more here.
Keywords: anti tubercular; tubercular activity; ring units; within bedaquiline ... See more keywords
Antibiotic bedaquiline effectively targets growth, survival and tumor angiogenesis of lung cancer through suppressing energy metabolism.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.10.136
Abstract: Tumor angiogenesis plays essential roles during lung cancer progression and metastasis. Therapeutic agent that targets both tumor cell and vascular endothelial cell may achieve additional anti-tumor efficacy. We demonstrate that bedaquiline, a FDA-approved antibiotic drug,… read more here.
Keywords: angiogenesis; bedaquiline; lung cancer; cancer ... See more keywords
Bedaquiline Phenotypic and Genotypic Susceptibility Testing, Work in Progress!
Sign Up to like & getrecommendations! Published in 2018 at "EBioMedicine"
DOI: 10.1016/j.ebiom.2018.02.006
Abstract: Criteria to definephenotypic resistance to bedaquiline (BDQ) are not variants were all found among susceptible isolates. All CFZ susceptible well determined and uncertainties around the genetic basis of resistance and cross resistance with clofazimine (CFZ)… read more here.
Keywords: susceptibility testing; susceptibility; bedaquiline; drug ... See more keywords
A structural insight of bedaquiline for the cardiotoxicity and hepatotoxicity.
Sign Up to like & getrecommendations! Published in 2019 at "Tuberculosis"
DOI: 10.1016/j.tube.2019.06.005
Abstract: Bedaquiline was approved by USFDA in 2012 for pulmonary MDR-TB. The IC50 value of bedaquiline was reported to be remarkably low (25 nM), effectively inhibiting mycobacterial ATP synthase. In addition to these obvious assets of bedaquiline,… read more here.
Keywords: insight bedaquiline; structural insight; cardiotoxicity hepatotoxicity; bedaquiline ... See more keywords
Targeting ATP Synthase by Bedaquiline as a Therapeutic Strategy to Sensitize Ovarian Cancer to Cisplatin
Sign Up to like & getrecommendations! Published in 2023 at "Nutrition and Cancer"
DOI: 10.1080/01635581.2023.2180825
Abstract: Abstract Cisplatin is a common chemotherapeutic drug for treating ovarian cancer, but its clinical efficacy is hampered by intrinsic and acquired resistance. Previous studies had shown inhibiting oxidative phosphorylation overcomes cisplatin resistance in ovarian cancer.… read more here.
Keywords: ovarian cancer; atp synthase; cisplatin; cancer ... See more keywords
A four-drug standardized short regimen for highly resistant TB in South-West Nigeria.
Sign Up to like & getrecommendations! Published in 2023 at "International health"
DOI: 10.1093/inthealth/ihad023
Abstract: BACKGROUND Patients with TB resistant to rifampicin (Rr-TB), and those with additional resistance to fluoroquinolones (pre-XDR-TB), should be treated with bedaquiline-pretomanid-linezolid-moxifloxacin and bedaquiline-pretomanid-linezolid, respectively. However, pretomanid is not yet widely available. METHODS This is a… read more here.
Keywords: drug standardized; bedaquiline; pre xdr; highly resistant ... See more keywords
Next-Generation Diarylquinolines Improve Sterilizing Activity of Regimens with Pretomanid and the Novel Oxazolidinone TBI-223 in a Mouse Tuberculosis Model
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DOI: 10.1128/aac.00035-23
Abstract: A regimen comprised of bedaquiline (BDQ, or B), pretomanid, and linezolid (BPaL) is the first oral 6-month regimen approved by the U.S. Food and Drug Administration and recommended by the World Health Organization for the… read more here.
Keywords: tuberculosis; tbaj 587; tbi 223; drug ... See more keywords
Determination of MIC Distribution and Mechanisms of Decreased Susceptibility to Bedaquiline among Clinical Isolates of Mycobacterium abscessus
Sign Up to like & getrecommendations! Published in 2018 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.00175-18
Abstract: ABSTRACT Chemotherapeutic options against Mycobacterium abscessus infections are very limited. Bedaquiline, a new antituberculosis (anti-TB) drug, is effective for the treatment of multidrug-resistant TB. However, few data are available on bedaquiline for treatment of M.… read more here.
Keywords: bedaquiline; mechanisms decreased; abscessus; decreased susceptibility ... See more keywords
Daily Dosing for Bedaquiline in Patients with Tuberculosis
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DOI: 10.1128/aac.00463-19
Abstract: The bedaquiline regimen for the treatment of multidrug-resistant tuberculosis (MDR-TB) in adults is a loading dose of 400 mg QD for 2 weeks followed by 200 mg thrice weekly (TIW) for 22 weeks. Most TB antibiotics administered with bedaquiline… read more here.
Keywords: patients tuberculosis; daily dosing; dosing bedaquiline; weeks followed ... See more keywords
Population Pharmacokinetic Modeling of Bedaquiline among Multidrug-Resistant Pulmonary Tuberculosis Patients from China
Sign Up to like & getrecommendations! Published in 2022 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.00811-22
Abstract: Bedaquiline has been widely used as a part of combination dosage regimens for the treatment of multidrug-resistant tuberculosis (MDR-TB) patients with limited options. Although the effectiveness and safety of bedaquiline have been demonstrated in clinical… read more here.
Keywords: tuberculosis; dosage; population pharmacokinetic; snp rs319952 ... See more keywords
In Vitro Activity of Bedaquiline against Nontuberculous Mycobacteria in China
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DOI: 10.1128/aac.02627-16
Abstract: ABSTRACT The main goal of our study was to evaluate the in vitro bedaquiline susceptibility of six prevalent species of pathogenic nontuberculous mycobacteria (NTM) in China. In addition, we investigated the potential molecular mechanisms contributing… read more here.
Keywords: nontuberculous mycobacteria; mycobacterium; bedaquiline; vitro activity ... See more keywords