Involvement of oxidative stress and mitochondrial mechanisms in air pollution-related neurobiological impairments
Sign Up to like & getrecommendations! Published in 2019 at "Neurobiology of Stress"
DOI: 10.1016/j.ynstr.2019.100205
Abstract: Background Vehicle exhaust emissions are known to be significant contributors to physical and psychological stress. Vehicle exhaust-induced stress and associated respiratory and cardiovascular complications are well-known, but the impact of this stress on the brain… read more here.
Keywords: behavioral deficits; stress; svee; vehicle exhaust ... See more keywords
P2X7 receptor inhibition ameliorates dendritic spine pathology and social behavioral deficits in Rett syndrome mice
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-15590-5
Abstract: Dysregulated immunity has been implicated in the pathogenesis of neurodevelopmental disorders but its contribution to synaptic and behavioral deficits in Rett syndrome (RTT) remains unknown. P2X7 receptors (P2X7Rs) are unique purinergic receptors with pro-inflammatory functions.… read more here.
Keywords: behavioral deficits; dendritic spine; p2x7; rett syndrome ... See more keywords
The behavioral deficits and cognitive impairment are correlated with decreased IGF-II and ERK in depressed mice induced by chronic unpredictable stress
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Neuroscience"
DOI: 10.1080/00207454.2017.1337014
Abstract: ABSTRACT Aim: To investigate the behavioral deficits, cognitive impairment and possible mechanisms induced by chronic unpredictable stress (CUS) in mice of different ages. Methods: The behaviors and cognition were tested using the open field test,… read more here.
Keywords: behavioral deficits; erk; igf erk; cognitive impairment ... See more keywords
Effect of varenicline on behavioral deficits in a rat model of Parkinson’s disease induced by unilateral 6-hydroxydopamine lesion of substantia nigra
Sign Up to like & getrecommendations! Published in 2018 at "Behavioural Pharmacology"
DOI: 10.1097/fbp.0000000000000355
Abstract: Nicotinic acetylcholine receptors (nAChRs) are implicated in the pathogenesis of Parkinson’s disease (PD). Varenicline tartrate is a partial agonist at &agr;4&bgr;2 and full agonist at &agr;7 neuronal nAChR subunits. A unilateral lesion of the substantia… read more here.
Keywords: lesion substantia; behavioral deficits; substantia nigra; effect varenicline ... See more keywords
Inhibiting α1‐adrenergic receptor signaling pathway ameliorates AD‐type pathologies and behavioral deficits in APPswe/PS1 mouse model
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Neurochemistry"
DOI: 10.1111/jnc.15603
Abstract: The role of α1 adrenergic receptors (α1‐ARs) signaling pathway in the pathogenesis of Alzheimer's disease (AD) has rarely been investigated. Clarifying the pathophysiological functions of α1‐ARs in the AD brain is helpful for better understanding… read more here.
Keywords: behavioral deficits; signaling pathway; deficits appswe; appswe ps1 ... See more keywords
Kdm6b Haploinsufficiency Causes ASD/ADHD-Like Behavioral Deficits in Mice
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Behavioral Neuroscience"
DOI: 10.3389/fnbeh.2022.905783
Abstract: Autism spectrum disorder (ASD) is a neurodevelopmental disease that has intellectual disability (ID) and attention-deficit/hyperactivity disorder (ADHD) as its common comorbidities. Recent genetic and clinical studies report that KDM6B, a gene encoding a histone H3… read more here.
Keywords: behavioral deficits; asd adhd; like behavioral; adhd like ... See more keywords
Social Behavioral Deficits in Krushinsky-Molodkina Rats, an Animal Model of Audiogenic Epilepsy
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Personalized Medicine"
DOI: 10.3390/jpm12122062
Abstract: In clinical practice, epilepsy is often comorbid with the autism spectrum disorders (ASDs). This warrants a search of animal models to uncover putative overlapping neuronal mechanisms. The Krushinsky-Molodkina (KM) rat strain is one of the… read more here.
Keywords: behavioral deficits; animal model; krushinsky molodkina; epilepsy ... See more keywords