Unexpected binding behaviors of bacterial Argonautes in human cells cast doubts on their use as targetable gene regulators
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DOI: 10.1371/journal.pone.0193818
Abstract: Prokaryotic Argonaute proteins (pAgos) have been proposed as an alternative to the CRISPR/Cas9 platform for gene editing. Although Argonaute from Natronobacterium gregoryi (NgAgo) was recently shown unable to cleave genomic DNA in mammalian cells, the… read more here.
Keywords: unexpected binding; binding behaviors; dna; gene ... See more keywords