Brown and Beige Adipose Tissues in Health and Disease.
Sign Up to like & getrecommendations! Published in 2017 at "Comprehensive Physiology"
DOI: 10.1002/cphy.c170001
Abstract: Brown and beige adipocytes arise from distinct developmental origins. Brown adipose tissue (BAT) develops embryonically from precursors that also give to skeletal muscle. Beige fat develops postnatally and is highly inducible. Beige fat recruitment is… read more here.
Keywords: bat beige; beige adipocytes; beige fat; beige ... See more keywords
Ethacrynic acid targets GSTM1 to ameliorate obesity by promoting browning of white adipocytes
Sign Up to like & getrecommendations! Published in 2020 at "Protein & Cell"
DOI: 10.1007/s13238-020-00717-7
Abstract: Obesity is caused by an imbalance between energy intake and expenditure, and has become a global epidemic with over 650 million adults affected. Adipose tissues in mammals are composed of white adipose tissue (WAT) and… read more here.
Keywords: white adipocytes; beige adipocytes; obesity; ethacrynic acid ... See more keywords
GSK126 alleviates the obesity phenotype by promoting the differentiation of thermogenic beige adipocytes in diet-induced obese mice.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.04.073
Abstract: A close relationship between epigenetic regulation and obesity has been demonstrated in several recent studies. Histone methyltransferase enhancer of Zeste homolog 2 (Ezh2), which mainly catalyzes trimethylation of histone H3K27 to form H3K27me3 was found… read more here.
Keywords: beige adipocytes; thermogenic beige; promoting differentiation; differentiation ... See more keywords
Artepillin C, a key component of Brazilian propolis, induces thermogenesis in inguinal white adipose tissue of mice through a creatine metabolism-related thermogenic pathway.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.9b07080
Abstract: Induction of beige adipocytes in white adipose tissue (WAT) is a potential therapeutic target for the treatment of obesity because beige adipocytes release excess energy via uncoupling protein 1-associated thermogenesis. In this study, we investigated… read more here.
Keywords: beige adipocytes; metabolism; metabolism related; creatine metabolism ... See more keywords
Human beige adipocytes for drug discovery and cell therapy in metabolic diseases
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-16340-3
Abstract: Human beige adipocytes (BAs) have potential utility for the development of therapeutics to treat diabetes and obesity-associated diseases. Although several reports have described the generation of beige adipocytes in vitro, their potential utility in cell… read more here.
Keywords: beige adipocytes; utility; metabolic diseases; beige ... See more keywords
An immune-beige adipocyte communication via nicotinic acetylcholine receptor signaling
Sign Up to like & getrecommendations! Published in 2018 at "Nature medicine"
DOI: 10.1038/s41591-018-0032-8
Abstract: Beige adipocytes have recently been shown to regulate energy dissipation when activated and help organisms defend against hypothermia and obesity. Prior reports indicate that beige-like adipocytes exist in adult humans and that they may present… read more here.
Keywords: immune; beige adipocytes; nicotinic acetylcholine; beige ... See more keywords
Jinlida Granules Reduce Obesity in db/db Mice by Activating Beige Adipocytes
Sign Up to like & getrecommendations! Published in 2022 at "BioMed Research International"
DOI: 10.1155/2022/4483009
Abstract: Recent studies indicate existence of beige adipocytes in adults. Upon activation, beige adipocytes burn energy for thermogenesis and contribute to regulation of energy balance. In this study, we have analyzed whether Jinlida granules (JLD) could… read more here.
Keywords: jld; beige adipocytes; beige; jinlida granules ... See more keywords
Characterization and Beige Adipogenic Potential of Human Embryo White Adipose Tissue-Derived Stem Cells
Sign Up to like & getrecommendations! Published in 2018 at "Cellular Physiology and Biochemistry"
DOI: 10.1159/000496042
Abstract: Background/Aims: Brown and beige adipocytes are widely recognized as potential therapeutic targets to treat obesity and related metabolic disorders, and the recruitment of brown and beige adipocytes is an essential aspect that requires attention. Although… read more here.
Keywords: beige adipocytes; adipogenic potential; white adipose; adipose tissue ... See more keywords
Perilipin 3 Deficiency Stimulates Thermogenic Beige Adipocytes Through PPARĪ± Activation
Sign Up to like & getrecommendations! Published in 2018 at "Diabetes"
DOI: 10.2337/db17-0983
Abstract: Beige adipocytes can dissipate energy as heat. Elaborate communication between metabolism and gene expression is important in the regulation of beige adipocytes. Although lipid droplet (LD) binding proteins play important roles in adipose tissue biology,… read more here.
Keywords: beige adipocytes; ppar activation; beige; plin3 ... See more keywords
Cellular Origins of Beige Fat Cells Revisited
Sign Up to like & getrecommendations! Published in 2019 at "Diabetes"
DOI: 10.2337/db19-0308
Abstract: Activated beige adipocytes have therapeutic potential due to their ability to improve glucose and lipid homeostasis. To date, the origin of beige adipocytes remains enigmatic. Whether beige cells arise through de novo differentiation from resident… read more here.
Keywords: beige adipocytes; beige fat; fat cells; beige ... See more keywords
1703-P: Altered UCP1 Expression in ADSC-Derived Beige Adipocytes Determines Mitochondrial ROS Production in T2DM Patients
Sign Up to like & getrecommendations! Published in 2020 at "Diabetes"
DOI: 10.2337/db20-1703-p
Abstract: Background: Under normal physiological conditions, adipose derived stem cells (ADSC) maintain adipose tissue homeostasis by responding to metabolic loading through proliferation and differentiation. Nevertheless, in T2DM their properties might be compromised. ADSC give rise to… read more here.
Keywords: t2dm patients; beige adipocytes; ros production; expression ... See more keywords