Brown and Beige Adipose Tissues in Health and Disease.
Sign Up to like & getrecommendations! Published in 2017 at "Comprehensive Physiology"
DOI: 10.1002/cphy.c170001
Abstract: Brown and beige adipocytes arise from distinct developmental origins. Brown adipose tissue (BAT) develops embryonically from precursors that also give to skeletal muscle. Beige fat develops postnatally and is highly inducible. Beige fat recruitment is… read more here.
Keywords: bat beige; beige adipocytes; beige fat; beige ... See more keywords
In vivo metabolic imaging and monitoring of brown and beige fat.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of biophotonics"
DOI: 10.1002/jbio.201800019
Abstract: Activation of the thermogenic brown and beige fat is an effective means to increasing whole-body energy expenditure. In this work, a unique label-free method was developed to quantitatively assess the metabolism and thermogenesis of mouse… read more here.
Keywords: imaging monitoring; beige fat; brown beige; monitoring brown ... See more keywords
Cold-Inducible SIRT6 Regulates Thermogenesis of Brown and Beige Fat.
Sign Up to like & getrecommendations! Published in 2017 at "Cell reports"
DOI: 10.1016/j.celrep.2017.06.069
Abstract: Promoting development and function of brown and beige fat may reduce obesity. Here, we show that fat SIRT6 expression is markedly induced by cold exposure and a β-adrenergic agonist. Deletion of SIRT6 in adipose tissue… read more here.
Keywords: inducible sirt6; beige fat; fat; brown beige ... See more keywords
Adrenergic-Independent Signaling via CHRNA2 Regulates Beige Fat Activation.
Sign Up to like & getrecommendations! Published in 2020 at "Developmental cell"
DOI: 10.1016/j.devcel.2020.05.017
Abstract: Maintaining energy homeostasis upon environmental challenges, such as cold or excess calorie intake, is essential to the fitness and survival of mammals. Drug discovery efforts targeting β-adrenergic signaling have not been fruitful after decades of… read more here.
Keywords: chrna2; beige fat; independent signaling; via chrna2 ... See more keywords
CHRNA2 as a marker for activated beige adipose tissue
Sign Up to like & getrecommendations! Published in 2018 at "Nature Reviews Endocrinology"
DOI: 10.1038/s41574-018-0038-9
Abstract: © 2018 Macmillan Publishers Limited, part of Springer Nature. All rights reserved. Nature reviews | Endocrinology Original article Jun, H. et al. An immune–beige adipocyte communication via nicotinic acetylcholine receptor signaling. Nat. Med. https://doi.org/10.1038/ s41591-018-0032-8… read more here.
Keywords: chrna2; endocrinology; beige fat; fat cells ... See more keywords
Blocking beige fat biogenesis.
Sign Up to like & getrecommendations! Published in 2022 at "Science signaling"
DOI: 10.1126/scisignal.ade6057
Abstract: A ubiquitin E3 ligase complex limits the generation of beige fat. read more here.
Keywords: beige fat; blocking beige; fat biogenesis;
IL-25-induced shifts in macrophage polarization promote development of beige fat and improve metabolic homeostasis in mice.
Sign Up to like & getrecommendations! Published in 2021 at "PLoS biology"
DOI: 10.1371/journal.pbio.3001348
Abstract: Beige fat dissipates energy and functions as a defense against cold and obesity, but the mechanism for its development is unclear. We found that interleukin (IL)-25 signaling through its cognate receptor, IL-17 receptor B (IL-17RB),… read more here.
Keywords: beige fat; induced shifts; fat; mice ... See more keywords
Cellular Origins of Beige Fat Cells Revisited
Sign Up to like & getrecommendations! Published in 2019 at "Diabetes"
DOI: 10.2337/db19-0308
Abstract: Activated beige adipocytes have therapeutic potential due to their ability to improve glucose and lipid homeostasis. To date, the origin of beige adipocytes remains enigmatic. Whether beige cells arise through de novo differentiation from resident… read more here.
Keywords: beige adipocytes; beige fat; fat cells; beige ... See more keywords
Beige Fat Maintenance; Toward a Sustained Metabolic Health
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2020.00634
Abstract: Understanding the mammalian energy balance can pave the way for future therapeutics that enhance energy expenditure as an anti-obesity and anti-diabetic strategy. Several studies showed that brown adipose tissue activity increases daily energy expenditure. However,… read more here.
Keywords: energy expenditure; beige fat; fat maintenance; beige adipocytes ... See more keywords